AI Article Synopsis
- Sucrose consumption in rats leads to hypertension, high triglycerides, and other metabolic syndrome characteristics, particularly affecting males and increasing cardiovascular disease risk.
- A study was conducted where male and female rats were given a 30% sucrose solution or tap water for varying durations, focusing on their cardiac function following ischemia-reperfusion stress tests.
- Findings revealed that sucrose treatment and age influenced heart performance, with notable gender differences, including higher coronary vascular resistance and cardiac enzyme retention in females, while males, especially those in the HTG group, experienced more arrhythmias and lethal complications.
Article Abstract
Sucrose-fed rats (HTG) develop hypertension, hypertriglyceridemia, and other features of the metabolic syndrome. This condition, nowadays a world epidemic, is more prevalent in males and increases the risk of cardiovascular diseases. Weanling male and female rats were given either tap water in control (C) or 30% sucrose solution in HTG groups and commercial rat chow for 3, 5, or 8 months. We studied possible variations in cardiac function, due to gender and length of treatment, in isolated heart after ischemia-reperfusion, since an impaired performance may be more easily detected under stress. Together, sucrose treatment and age affected all cardiac variables. Gender had significant effect on coronary vascular resistance and postischemic levels of the enzyme CK-MB; the percentages of retained cardiac enzymes after ischemia were higher in C and HTG females. C and HTG males had a higher incidence of arrhythmias than females, but only HTG males suffered lethal ventricular fibrillation.
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| http://dx.doi.org/10.1080/10641960500468235 | DOI Listing |
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