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Anterior Uveitis and Uveal Depigmentation in a Dog With Vitiligo.

Case Rep Vet Med

January 2025

Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.

The objective of this study is to describe the clinical and histologic features of a dog that developed anterior uveitis and uveal depigmentation in association with vitiligo. A 3-year-old, female-spayed, Bernese Mountain Dog with a history of bilateral idiopathic anterior uveitis developed iris depigmentation, leukotrichia, and skin depigmentation. The initial diagnostic evaluation for uveitis was unremarkable, including general bloodwork, urinalysis, infectious disease testing, thoracic radiographs, and abdominal ultrasound.

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  • Familial progressive hyperpigmentation with or without hypopigmentation (FPHH) is an autosomal dominant skin disorder caused by mutations in the KITLG gene, leading to widespread hyperpigmentation and distinct skin lesions.
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