AI Article Synopsis
- Researchers developed new PPARdelta agonists based on the structure of GW2433, a non-selective ligand.
- One compound, referred to as Compound 1, is effective at a concentration of 10 nM and is bioavailable.
- Importantly, Compound 1 does not interact with other PPAR subtypes even at concentrations up to 10 microM, making it valuable for studying the effects of selectively activating PPARdelta.
Article Abstract
A series of highly potent and selective PPARdelta agonists is described using the known non-selective ligand GW2433 as a structural template. Compound 1 is bioavailable, potent (10 nM), and shows no cross-activity with other PPAR subtypes up to 10 microM, making it a useful tool in studying the biological effects of selective PPARdelta activation.
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| http://dx.doi.org/10.1016/j.bmcl.2006.02.079 | DOI Listing |
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