Human T-cell lymphotropic virus type-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is chronic inflammatory disease of the spinal cord characterized by perivascular lymphocytic cuffing and parenchymal lymphocytic infiltration. In this study using flow cytometry, we have investigated the T-cell receptor (TCR) Vbeta repertoire of peripheral blood T lymphocytes in 8 HAM/TSP patients, 10 HTLV-1 infected healthy carriers, and 11 uninfected healthy controls to determine if there is a biased usage of TCR Vbeta. We found that TCR Vbeta7.2 was under-utilized and Vbeta12 was over-utilized in CD4+ T cells of HTLV-1 infected individuals compared with healthy uninfected controls, whereas there were no such differences in CD8+ T cells. Comparison of Vbeta repertoire changes before and after interferon-alpha (IFN-alpha) treatment for HAM/TSP revealed that one out of five patients showed dramatic decrease of specific Vbeta in CD8+ T cells. Our results suggest that dominant Vbeta subpopulations in CD4+ T cells evolved associated with chronic HTLV-1 infection, and IFN-alpha treatment for HAM/TSP does not induce a specific pattern of TCR Vbeta changes.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jns.2006.02.004 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Severe COVID-19 can trigger a cytokine storm, leading to acute respiratory distress syndrome (ARDS) with similarities to superantigen-induced toxic shock syndrome. An outstanding question is whether SARS-CoV-2 protein sequences can directly induce inflammatory responses. In this study, we identify a region in the SARS-CoV-2 S2 spike protein with sequence homology to bacterial super-antigens (termed P3).
View Article and Find Full Text PDFEndogenous antigens shape the transcriptome and TCR repertoire in an autoimmune arthritis model.
J Clin Invest
November 2024
Rosalind Russell and Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, United States of America.
Article Synopsis
- - The study investigates how impaired signaling in naïve CD4+ T cells leads to the development of pathogenic autoreactive cells, which play a role in autoimmune arthritis, specifically using SKG mice with a mutated Zap70 gene.
- - Researchers found these pathogenic T cells had increased expression of activation and cytokine-related genes, but reduced expression of markers that usually promote tolerance compared to healthy cells.
- - The presence of specific TCR variable beta chains linked to superantigens from mouse retroviruses suggests that these viral elements may disrupt normal immune tolerance, fostering the development of self-reactive CD4+ T cells into harmful effector cells, with potential therapeutic implications.
The characteristics of T-cell receptor repertoire in relation to systemic immune response of patients with ischemic stroke.
J Neurochem
October 2024
Department of Neurology, People's Hospital of Zhengzhou University & Henan Provincial People's Hospital, Zhengzhou, P. R. China.
T lymphocytes play a vital role in the immune-inflammatory response following a stroke. However, the specific mechanisms behind the contrasting functions of T cells in the brain and peripheral tissues after a stroke remain unclear and require further investigation. T-cell receptors (TCRs) are essential in controlling how T lymphocytes develop and become active.
View Article and Find Full Text PDFSARS-CoV-2-Specific T-Cell as a Potent Therapeutic Strategy against Immune Evasion of Emerging COVID-19 Variants.
Int J Mol Sci
September 2024
Institute for Translational Research and Molecular Imaging, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Article Synopsis
- * Researchers investigated using virus-specific T cells (VSTs) from donors to enhance immune responses against SARS-CoV-2 infections.
- * Findings show that these VSTs effectively target multiple viral antigens, maintaining strong cytotoxic effects against both original and variant strains, suggesting their potential for future therapies.
Computational Analysis of T-Cell Receptor Repertoire Workflow: From T-Cell Isolation to Bioinformatics Analysis.
Methods Mol Biol
September 2024
Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
The T-cell receptor (TCR) is the key molecule involved in the adaptive immune response. It is generated by the V(D)J recombination, responsible of the enormous diversity of the TCR repertoire, a crucial feature determining the individual capability to response to antigens and to build immunological memory. A pivotal role in the recognition of antigen is played by the hypervariable complementarity-determining region 3 (CDR3) of the V-beta chain of TCR.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!