AI Article Synopsis
- The study investigated how blocking cerebral lymphatic drainage affects blood flow and swelling in the brain after subarachnoid hemorrhage (SAH) in rats.
- Rats were divided into three groups: non-SAH, SAH, and SAH with cervical lymphatic blockade (CLB), with results showing a significant drop in regional cerebral blood flow (rCBF) and increased brain water content in the SAH groups.
- The blockade of lymphatic drainage worsened both the reduction in rCBF and the increase in intracranial pressure (ICP), suggesting that this blockage exacerbates brain damage following SAH.
Article Abstract
The study was designed to observe the influence of blockade of cerebral lymphatic drainage on the regional cerebral blood flow (rCBF) and brain edema after experimental subarachnoid hemorrhage (SAH). Wistar rats were divided into non-SAH, SAH, and SAH plus cervical lymphatic blockade (SAH + CLB) groups. Autologous arterial hemolysate was injected into rat's cisterna magna to induce SAH. The rCBF was recorded continuously by a laser Doppler flowmeter. Intracranial pressure (ICP) was also monitored. After 24 hours and 72 hours of SAH, the rats were sacrificed and the brain was harvested for water content detection. It was found that there was no obvious change of rCBF and brain water content during the experiment in non-SAH group. An immediate and persistent drop in rCBF was found in SAH group. The drop in rCBF was more obvious in SAH + CLB group. CLB also worsened the SAH-induced increase in ICP. The brain water content 24 hours and 72 hours after induction of SAH in SAH group increased significantly. CLB led to a further increase of brain water content. In conclusion, blockade of cerebral lymphatic drainage pathway deteriorates the secondary cerebral ischemia and brain edema after SAH.
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