AI Article Synopsis

  • Variable responses to corticosteroids occur in various diseases, especially asthma, where these medications are crucial for treatment.
  • Factors influencing why some patients do not respond well to steroids are discussed, along with management strategies for these patients.
  • The text also explores the molecular mechanisms that contribute to the differing responses to corticosteroid treatment.

Article Abstract

Variable responses to corticosteroids are seen in a multitude of disease states including asthma, a disease in which these anti-inflammatory medications play a central role in both acute and chronic management. Clinical factors associated with steroid insensitivity, strategies for managing patients with steroid insensitivity, and underlying molecular mechanisms responsible for variable responses to corticosteroids are described.

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http://dx.doi.org/10.1016/j.ccm.2005.10.005DOI Listing

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