A convenient synthesis of gamma-functionalized cyclopentenones.

Beilstein J Org Chem

Laboratoire de Chimie Organique & Organométallique, Faculté des Sciences, Campus Universitaire 2092-Tunis, Tunisie.

Published: October 2005

The synthesis of gamma-functionalized cyclopentenones was carried out in a few steps, starting firstly with the preparation of nitroketonic intermediates 2, which were readily transformed into 1,4-diketones using the Nef conversion. The intramolecular cyclization of the gamma-diketones 3 in a basic medium, led to the functionalized cyclopentenones 4.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1399459PMC
http://dx.doi.org/10.1186/1860-5397-1-11DOI Listing

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