AI Article Synopsis
- Microbicides are drugs applied vaginally or rectally to prevent HIV and other STDs, with around 30 products currently in trials.
- Research has shown promising results from various studies, but large-scale clinical trials are needed to confirm their effectiveness.
- Combining different microbicides may provide better protection for uninfected individuals and could reduce the risk of transmission among those who are already infected with HIV.
Article Abstract
Microbicides are vaginally or rectally applied drugs that inhibit HIV and other sexually transmitted pathogens. About 30 microbicidal products are being studied in preclinical and clinical trials. Data from in vitro, animal, and in vivo investigations with candidate microbicidal compounds support a proof of concept, although large-scale clinical trials will determine efficacy. Because there are multiple targets for HIV infection in the genital tract, synergistic combinations of microbicides will probably offer the greatest protection for non-HIV-infected persons and might decrease transmissibility when used by those infected with HIV.
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