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Insights into NEK2 inhibitors as antitumor agents: From mechanisms to potential therapeutics.
Eur J Med Chem
January 2025
Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, Institute of Respiratory Healthand, Department of Frontiers Science Center for Disease-related Molecular Network, Core Facilities, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. Electronic address:
NEK2, a serine/threonine protein kinase, is integral to mitotic events such as centrosome duplication and separation, microtubule stabilization, spindle assembly checkpoint, and kinetochore attachment. However, NEK2 overexpression leads to centrosome amplification and chromosomal instability, which are significantly associated with various malignancies, including liver, breast, and non-small cell lung cancer. This overexpression could facilitate tumor development and confer resistance to therapy by promoting aberrant cell division and centrosome amplification.
View Article and Find Full Text PDFStructural and Functional Remodeling for Elite Cyclists During Exercise; Pressure Volume Loops and Hemodynamic Forces Analysis.
Am J Physiol Heart Circ Physiol
January 2025
Sport Medicine Unit, Careggi University Hospital, Via delle Oblate 4, 50134 Florence, Italy.
The study was designed to investigate the pattern of intraventricular Hemo-Dynamic Forces (HDF) and myocardial performance during exercise in Elite Cyclists (EC). Transthoracic stress echocardiography was performed on nineteen EC and thirteen age-matched sedentary controls (SC) at three incremental exercise intensities based on Heart Rate Reserve (HRR). Left Ventricular (LV) HDF were computed from echocardiography long-axis data sets using a novel technique based on endocardial boundary tracking, both in apex-base and latero-septal directions.
View Article and Find Full Text PDFHypothesis for Molecular Evolution in the Pre-Cellular Stage of the Origin of Life.
Wiley Interdiscip Rev RNA
January 2025
Institute for Ocean Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen, People's Republic of China.
Life was originated from inorganic world and had experienced a long period of evolution in about 3.8 billion years. The time for emergence of the pioneer creations on Earth is debatable nowadays, and how the scenario for the prebiotic molecular interactions is still mysterious.
View Article and Find Full Text PDFComparative analysis of the structure and content of N-glycans from different commercial whey protein materials.
J Food Sci
January 2025
College of Food Science and Engineering, Tianjin University of Science & Technology, Tianjin, China.
Infant formulas are constantly being updated and upgraded, and N-glycans are functional glycans that have not been fully exploited to date. Commercial whey protein materials are often used as basic ingredients in infant formulas. Therefore, it is important to study N-glycans in commercial whey protein materials.
View Article and Find Full Text PDFPhylogenetic position of the subfamily Symphrasinae (Insecta: Neuroptera), its intergeneric relationships and evolution of the raptorial condition within Mantispoidea.
Invertebr Syst
January 2025
Instituto de Biología, UNAM, Departamento de Zoología, Colección Nacional de Insectos, Apartado Postal 70-153, 04510, Ciudad de México, Mexico.
The superfamily Mantispoidea (Insecta: Neuroptera) includes the families Berothidae, Rhachiberothidae and Mantispidae. Among these taxa, the last two are collectively known as Raptorial Mantispoidea due to the presence of grasping forelegs for predatory habits. The Mantispidae classically included the subfamilies Symphrasinae, Drepanicinae, Calomantispinae and Mantispinae, yet recent research challenged this classification scheme as well as the monophyly of this family resulting in Symphrasinae being transferred to Rhachiberothidae.
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