Purpose: To assess the enamel-protective potential of a newly devised adhesive patch for smooth enamel sealing.
Materials And Methods: Approximal surfaces of 30 extracted molars were divided into three areas: the buccal thirds were treated with a flowable composite (Tetric Flow, Ivoclar Vivadent) and served as negative control sites, the lingual thirds were left untreated and served as positive control sites, and the middle thirds served as the test areas. This was sealed with either 1. a twofold application of an unfilled resin (Heliobond, Ivoclar Vivadent), 2. an adhesive prototype patch (Ivoclar Vivadent), or 3. an adhesive patch in combination with a flowable composite. After thermomechanical loading and demineralization in a microbial-based artificial caries chamber, demineralization depth was assessed using a confocal laser scanning microscope.
Results: Negative control sites treated with the flowable composite showed no signs of demineralization. Areas treated with the patch showed no signs of demineralization, irrespective of whether it was used in combination with a flowable composite or directly bonded to the enamel. Caries-like lesions in untreated sites showed a mean depth of 134.3 +/- 35.9 microm. Demineralization depth at sites treated with the unfilled resin was 76.2 +/- 26.5 microm (p = 0.023).
Conclusions: Under the conditions of the present study, the adhesive patch under investigation completely protected the underlying enamel from demineralization. This merits further study to assess its potential as an interproximal sealant.
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Expert Opin Drug Deliv
January 2025
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning, China.
Introduction: Transdermal patches offer a unique advantage by providing extended therapeutic benefits while maintaining stable plasma drug concentration. The efficacy and safety of patches depend significantly on their ability to adhere to the skin, a feature influenced by various external and internal factors.
Areas Covered: The review primarily focuses on the fundamental aspects of adhesion in transdermal patches, including basic information about the skin, the underlying principles of adhesion, drug delivery, and adhesion characteristics of pressure sensitive adhesives (PSAs), adhesion issues, impact factors, strategies to improve patch adhesion, and relevant molecular mechanisms.
J Biomater Appl
January 2025
BEST/CB3S, UMR CNRS 7244, Institut Galilée, Université Sorbonne Paris Nord, Villetaneuse, France.
Myelomeningocele (MMC) is a congenital defect of the spine characterized by meningeal and spinal cord protrusion through open vertebral archs, and its exposure to the amniotic fluid. Given that the progression of neuronal loss begins early in fetal life, an early coverage of the defect is required to improve the neurological outcomes. Several studies have proposed patches as an alternative to full surgical repair, to achieve an early protection of the spine and possibly reduce the rate of complications of current prenatal surgical procedures.
View Article and Find Full Text PDFTalanta
January 2025
Department of Materials Science and Engineering, Sharif University of Technology, Azadi Avenue, Tehran, 14588-89694, Iran; Center for Bioscience and Technology, Institute for Convergence Science and Technology, Sharif University of Technology, Tehran, 14588-89694, Iran; Fraunhofer Institute for Manufacturing Technology and Advanced Materials, 28359, Bremen, Germany. Electronic address:
Real-time monitoring of sweat using wearable devices faces challenges such as limited adhesion, mechanical flexibility, and accurate detection. In this work, we present a stretchable, adhesive, bilayer hydrogel-based patch designed for continuous monitoring of sweat pH and glucose levels using AI-assisted smartphones. The patch is composed of a bottom PVA hydrogel layer functionalized with colorimetric reagents and glucose oxidase enzyme, while the top PVA-sucrose layer enhances skin adhesion and protects against air moisture.
View Article and Find Full Text PDFBiomater Sci
January 2025
Department of Nanobiomedical Science & BK21 FOUR micropatterned shape-memory NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 31116, Republic of Korea.
A scaffold design for tendon regeneration has been proposed, which mimics the microstructural features of tendons and provides appropriate mechanical properties. We synthesized a temperature-triggered shape-memory polymer (SMP) using the ring-opening polymerization of polycaprolactone (PCL) with polyethylene glycol (PEG) as a macroinitiator. We fabricated a micropatterned patch using SMP capillary force lithography, which mimicked a native tendon, for providing physical cues and guiding effects.
View Article and Find Full Text PDFContact Dermatitis
January 2025
Department of Dermatology and Venereology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Türkiye.
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