The impact of Niels Bohr's 1932 "Light and Life" lecture on Max Delbrück's lifelong search for a form of "complementarity" in biology is well documented and much discussed, but the precise nature of that influence remains subject to misunderstanding. The standard reading, which sees Delbrück's transition from physics into biology as inspired by the hope that investigation of biological phenomena might lead to a breakthrough discovery of new laws of physics, is colored much more by Erwin Schrödinger's What Is Life? (1944) than is often acknowledged. Bohr's view was that teleological and mechanistic descriptions are mutually exclusive yet jointly necessary for an exhaustive understanding of life. Although Delbrück's approach was empirical and less self-consciously philosophical, he shared Bohr's hope that scientific investigation would vindicate the view that at least some aspects of life are not reducible to physico-chemical terms.
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http://dx.doi.org/10.1086/498591 | DOI Listing |
Drug Discov Today
September 2024
School of Science, Shenzhen Key Laboratory of Flexible Printed Electronics Technology, Shenzhen Key Laboratory of Advanced Functional Carbon Materials Research and Comprehensive Application, Harbin Institute of Technology, Shenzhen 518055 China. Electronic address:
This review focuses on the advancements in manganese (Mn) complex-based magnetic resonance imaging (MRI) agents for imaging different diseases. Here we emphasize the unique redox properties of Mn to deliver innovative MRI contrast agents, including small molecules, nanoparticles (NPs), metal-organic frameworks (MOFs), and polymer hybrids. Aspects of their rational design have been discussed, including size dependence, morphology tuning, surface property enhancement, etc.
View Article and Find Full Text PDFNanoscale
May 2024
School of Science, Shenzhen Key Laboratory of Flexible Printed Electronics Technology, Shenzhen Key Laboratory of Advanced Functional Carbon Materials Research and Comprehensive Application, Harbin Institute of Technology, Shenzhen-518055, China.
Cancer, the leading global cause of mortality, poses a formidable challenge for treatment. The effectiveness of cancer therapies, ranging from chemotherapy to immunotherapy, relies on the precise delivery of therapeutic agents to tumor tissues. Nanobiohybrids, resulting from the fusion of bacteria with nanomaterials, constitute a promising delivery system.
View Article and Find Full Text PDFJ Christ Nurs
December 2023
Caitlin Lawrence, BSN, RN, is a missionary serving with SIM for the past 6 years. She graduated from Quinnipiac University with her BSN. Prior to Bolivia, Caitlin obtained her oncology nurse certification and worked with hematology and oncology patients for 9 years.
Nat Commun
October 2023
UTS-SUSTech Joint Research Centre for Biomedical Materials and Devices, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China.
Skeletal disorders are commonly diagnosed by X-ray imaging, but the radiation limits its use. Optical imaging through the near-infrared-II window (NIR-II, 1000-1700 nm) can penetrate deep tissues without radiation risk, but the targeting of contrast agent is non-specific. Here, we report that lanthanide-doped nanocrystals can passively target the bone marrow, which can be effective for over two months.
View Article and Find Full Text PDFJAMA Surg
November 2023
Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Importance: Most ovarian cancers originate in the fimbriated end of the fallopian tube. This has led to the hypothesis that surgical resection of the fallopian tubes at the time of gynecologic and nongynecologic surgical procedures-referred to as an opportunistic salpingectomy-may prevent the development of epithelial ovarian cancer for women at an average risk of developing the disease.
Objective: To compile a comprehensive, state-of-the-science review examining the current landscape of performing bilateral salpingectomy for ovarian cancer prevention.
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