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Comparison of different microbiome analysis pipelines to validate their reproducibility of gastric mucosal microbiome composition.
mSystems
January 2025
Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
Microbiome analysis has become a crucial tool for basic and translational research due to its potential for translation into clinical practice. However, there is ongoing controversy regarding the comparability of different bioinformatic analysis platforms and a lack of recognized standards, which might have an impact on the translational potential of results. This study investigates how the performance of different microbiome analysis platforms impacts the final results of mucosal microbiome signatures.
View Article and Find Full Text PDFDiscovery of Isograndidentatin D, a Novel Phenolic Glycoside, and Anti- Phenolics from Twigs.
Plants (Basel)
December 2024
School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Anderss (Salicaceae), commonly referred to as Korean willow, is native to East Asia, particularly Korea and China, and it has been used in traditional Korean folk medicine for its potent anti-inflammatory, analgesic, and antioxidant properties. In our ongoing research efforts to discover biologically new natural products, phytochemical analysis on an ethanolic extract of twigs yielded the isolation and identification of ten phenolic compounds (-), including a newly discovered phenolic glycoside () named isograndidentatin D, isolated via HPLC purification. The structure of compound was determined through extensive 1D and 2D NMR spectral data analysis and high-resolution electrospray ionization mass spectrometry (HR-ESIMS).
View Article and Find Full Text PDFA History of the Discovery of Helicobacter Pylori, with Special Reference to Giulio Bizzozero.
J Gastrointestin Liver Dis
December 2024
Lynda K and David M Underwood Center for Digestive Disorders, Houston Methodist Hospital and Weill Cornell Medical College, Houston, Texas, USA.
Helicobacter pylori is a microorganism that is highly prevalent in mankind and closely linked to several gastroduodenal disorders. Though Helicobacter pylori was introduced to the scientific community in 1983 by Robin Warren and Barry Marshall, a closely related Helicobacter species had been described one hundred years earlier by the Italian pathologist Giulio Bizzozero in the canine stomach. In this review we analyze the different steps involved in the discovery of Helicobacter and provide a biography of the pioneer Giulio Bizzozero.
View Article and Find Full Text PDFBAFF Blockade Attenuates B Cell MALT Formation in Conditional Nlrc5-Deficient Mice With Helicobacter felis Infection.
Eur J Immunol
December 2024
Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia.
Helicobacter infection is a key cause of gastric B cell mucosa-associated lymphoid tissue (MALT) lymphoma. This study examined the role of B cell-activating factor (BAFF), a major driver of B cell proliferation and many B cell disorders, in this malignancy using a model in which conditional knockout mice for NOD-like receptor family CARD domain-containing 5 (Nlrc5) are infected with Helicobacter felis. Gastric BAFF production was significantly increased in H.
View Article and Find Full Text PDFCrystal structure of glutamyl-tRNA synthetase from Helicobacter pylori.
Acta Crystallogr F Struct Biol Commun
December 2024
Dartmouth Cancer Center, One Medical Center Drive, Lebanon, NH 03756, USA.
Article Synopsis
- * There is a growing need for alternative treatments due to drug resistance in H. pylori, leading to research at the Seattle Structural Genomics Center for Infectious Disease (SSGCID) into potential drug targets, specifically Glutamyl-tRNA synthetase (GluRS).
- * The SSGCID has successfully determined the structure of H. pylori GluRS, which shares significant similarities with other bacterial GluRS, presenting opportunities for drug discovery aimed at developing new antibacterials to combat H. pylori infections.
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