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Impact of Age and Sex on Viral Load in Hepatitis C Virus Infection.
Viruses
December 2024
Department of Translational Medicine, Università del Piemonte Orientale, 28100 Novara, Italy.
The determinants of hepatitis C virus (HCV) viral load remain incompletely understood and may differ in females, who are relatively protected from the consequences of HCV infection during their reproductive years. We aimed to evaluate how age affects the relationship between sex and viral load. = 922 patients (males = 497, median age 62 years), all naïve to direct antiviral agents, were studied.
View Article and Find Full Text PDFEvaluation of Biologics ACE2/Ang(1-7) Encapsulated in Plant Cells for FDA Approval: Safety and Toxicology Studies.
Pharmaceutics
December 2024
Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
For several decades, protein drugs (biologics) made in cell cultures have been delivered as sterile injections, decreasing their affordability and patient preference. Angiotensin Converting Enzyme 2 (ACE2) gum is the first engineered human blood protein expressed in plant cells approved by the FDA without the need for purification and is a cold-chain and noninvasive drug delivery. This biologic is currently being evaluated in human clinical studies to debulk SARS-CoV-2 in the oral cavity to reduce coronavirus infection/transmission (NCT00543318).
View Article and Find Full Text PDFPsychoneurological Links Contributing to Body Mass Index and Eating Disorder Severity.
Nutrients
January 2025
Department of Psychobiology and Methodology, Universitat Autònoma de Barcelona, 08193 Barcelona, Spain.
Background-objectives: Multiple dynamic interacting factors contribute to the presence and progression of eating disorders (ED). Empirical research has provided mixed findings regarding the mechanisms explaining the contribution of body mass index (BMI) to the diverse ED endophenotypes. The present study aims to evaluate the underlying processes (direct and indirect effects) contributing to BMI and ED severity, considering the contribution of multiple neuropsychological constructs.
View Article and Find Full Text PDFThe Impact of Social Media on Eating Disorder Risk and Self-Esteem Among Adolescents and Young Adults: A Psychosocial Analysis in Individuals Aged 16-25.
Nutrients
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Department of Health Promotion, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, ul. Piekarska 18, 41-902 Bytom, Poland.
Background/objectives: Eating disorders (EDs) result from complex interactions of biological, psychological, social, and cultural factors, disproportionately affecting adolescents and young adults. Social media, peer pressure, and self-esteem issues contribute to ED prevalence. This study examines ED risk, eating behaviors, and self-esteem among individuals aged 16-25, exploring differences by gender, age, and social media usage.
View Article and Find Full Text PDFHow Hormonal Balance Changes Lives in Women with Psoriasis.
J Clin Med
January 2025
Dermatology Unit, Department of Medicine (DIMED), University of Padua, 35121 Padua, Italy.
Psoriasis is a chronic, immune-mediated skin disease significantly impacting women, with disease severity often modulated by hormonal fluctuations. This review examines the influence of hormonal changes on the course of psoriasis in women, focusing on key life stages-including the menstrual cycle, pregnancy, postpartum, and menopause-and their impact on disease progression and symptomatology. Estrogen, the principal female sex hormone, plays a critical role in immune modulation.
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