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Naevoid hyperkeratosis of the nipple and/or areola.

Br J Dermatol

December 2024

Department of Dermatology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.

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Article Synopsis
  • * The study presents cases of siblings and an additional patient with ABCA12 variants who exhibited symptoms not typical of congenital ichthyosis, instead resembling pityriasis rubra pilaris (PRP).
  • * All three patients displayed unique skin characteristics, such as geographic unaffected areas, and had similar histological features to PRP, indicating a broader range of possible symptoms associated with ABCA12 variants than previously understood.
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Article Synopsis
  • - Nevoid hyperkeratosis of the nipple and areola (NHKNA) is a rare skin condition, especially in its type II form, which can develop from irritant skin conditions like erosive papulonodular dermatitis that occurs in areas prone to friction and moisture.
  • - The case discussed involves a patient who had previously suffered from erosive papulonodular dermatitis after undergoing an ileostomy, later showing classic signs of NHKNA, which were confirmed through clinical and histological analysis.
  • - Treatment for type II NHKNA usually involves addressing the underlying skin issue; in this instance, reversing the ileostomy and implementing barrier protection successfully resolved the patient's NHKNA lesions.
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