AI Article Synopsis
- Sarcoidosis is a chronic disorder that significantly affects the health-related quality of life (HRQL) of patients, particularly through respiratory issues like bronchial obstruction.
- The study evaluated 129 patients with confirmed sarcoidosis using the St. George's respiratory questionnaire (SGRQ) and found that various clinical factors, such as gender and disease stage, influenced HRQL scores.
- Results indicated that the SGRQ is a valid tool for assessing HRQL in sarcoidosis patients, but more research is needed to confirm its consistency and responsiveness in this group.
Article Abstract
Introduction: Sarcoidosis is a chronic multisystem disorder which has a great impact on health-related quality of life (HRQL). Patients with sarcoidosis very often present with bronchial obstruction. The purpose of this study was to assess the impact of respiratory disorder on general HRQL using St. George's respiratory questionnaire (SGRQ).
Material And Methods: We examined 129 patients with histologically proven sarcoidosis. All patients underwent clinical examination, chest X-ray and spirometry, and in all skin prick tests and sera ACE and IgE were determined. Afterwards, they filled out SGRQ, and scores were compared with clinical and radiological findings, and also with serum markers of the disease.
Results: Mean activity score values were significantly lower in men, in patients with newly diagnosed disease, and in patients with elevated ACE. Patients with extrathoracic disease had significantly higher scores. Clinical course showed significant correlation with impact and total score, and the number of relapses with the activity score. SGRQ scores significantly correlated with serum IgE and with most spirometric parameters.
Conclusion: Our data revealed a high validity of SGRQ in patients with sarcoidosis and a great influence of respiratory disorders on general health-related quality of life in these patients. However, reproducibility and responsiveness of SGRQ is yet to be established in patients with sarcoidosis.
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