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The ethics of synthetic DNA.
J Med Ethics
November 2024
Clinical Sciences, Lund University, Lund, Sweden.
In this paper, we discuss the ethical concerns that may arise from the synthesis of human DNA. To date, only small stretches of DNA have been constructed, but the prospect of generating human genomes is becoming feasible. At the same time, the significance of genes for identity, health and reproduction is coming under increased scrutiny.
View Article and Find Full Text PDFDisulfidptosis-related gene expression reflects the prognosis of drug-resistant cancer patients and inhibition of MYH9 reverses sorafenib resistance.
Transl Oncol
November 2024
Department of Gastroenterology, Shanghai Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200336, China. Electronic address:
The onset of drug resistance in advanced cancer patients markedly diminishes their prognosis. Recently, disulfidptosis, a novel form of cell death, has been identified, triggered by excessive disulfide formation leading to cell shrinkage and F-actin contraction. Previous studies have identified 15 essential genes (FLNA, FLNB, MYH9, TLN1, ACTB, MYL6, MYH10, CAPZB, DSTN, IQGAP1, ACTN4, PDLIM1, CD2AP, INF2, SLC7A11) associated with disulfidptosis.
View Article and Find Full Text PDFComprehensive analysis of mitochondrial dynamic-related genes on their functions and prognostic values for glioblastoma multiforme.
Genes Dis
September 2024
Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Obstetrics and Gynecology Hospital, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai 200433, China.
Klinefelter syndrome: etiology and clinical considerations in male infertility†.
Biol Reprod
September 2024
Reproductive Endocrinology and Regulation Laboratory, Department of Obstetric and Gynecologic, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Klinefelter syndrome (KS) is the most prevalent chromosomal disorder occurring in males. It is defined by an additional X chromosome, 47,XXY, resulting from errors in chromosomal segregation during parental gametogenesis. A major phenotype is impaired reproductive function, in the form of low testosterone and infertility.
View Article and Find Full Text PDFParental kinship coefficient but not paternal coloration predicts early offspring growth in lake char.
Heredity (Edinb)
May 2024
Department of Ecology & Evolution, University of Lausanne, Lausanne, Switzerland.
The 'good genes' hypotheses of sexual selection predict that females prefer males with strong ornaments because they are in good health and vigor and can afford the costs of the ornaments. A key assumption of this concept is that male health and vigor are useful predictors of genetic quality and hence offspring performance. We tested this prediction in wild-caught lake char (Salvelinus umbla) whose breeding coloration is known to reveal aspects of male health.
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