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Melanoma-derived extracellular vesicles transfer proangiogenic factors.
Oncol Res
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Department of Glycoconjugate Biochemistry, Faculty of Biology, Institute of Zoology and Biomedical Research, Jagiellonian University, Krakow, 30-387, Poland.
Angiogenesis, the expansion of pre-existing vascular networks, is crucial for normal organ growth and tissue repair, but is also involved in various pathologies, including inflammation, ischemia, diabetes, and cancer. In solid tumors, angiogenesis supports growth, nutrient delivery, waste removal, and metastasis. Tumors can induce angiogenesis through proangiogenic factors including VEGF, FGF-2, PDGF, angiopoietins, HGF, TNF, IL-6, SCF, tryptase, and chymase.
View Article and Find Full Text PDFMechanisms of the Photomechanical Response in Thin-Film Dye-Doped Glassy Polymers.
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January 2025
Department of Physics, Washington State University, Pullman, WA 99163, USA.
This work aims to determine the mechanism of the photomechanical response of poly(Methyl methacrylate) polymer doped with the photo-isomerizable dye Disperse Red 1 using the non-isomerizable dye Disperse Orange 11 as a control to isolate photoisomerization. Samples are free-standing thin films with thickness that is small compared with the optical skin depth to assure uniform illumination and photomechanical response throughout their volume, which differentiates these studies from most others. Polarization-dependent measurements of the photomechanical stress response are used to deconvolute the contributions of angular hole burning, molecular reorientation and photothermal heating.
View Article and Find Full Text PDFMealworm-Derived Protein Hydrolysates Enhance Adipogenic Differentiation via Mitotic Clonal Expansion in 3T3-L1 Cells.
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Department of Food Science and Technology, Keimyung University, Daegu 42601, Republic of Korea.
Adipocytes secrete adipokines, bioactive molecules crucial for various physiological processes, such as enhancing insulin sensitivity, promoting wound healing, supporting hair growth, and exhibiting anti-aging effects on the skin. With the growing global demand for sustainable and alternative protein sources, insect-derived proteins, particularly from (mealworms), have gained attention due to their high nutritional value and functional bioactivities. This study aims to explore the potential of mealworm-derived protein hydrolysates as novel bioactive materials for promoting adipogenesis and improving adipokine expression, with applications in metabolic health and skin regeneration.
View Article and Find Full Text PDFGeneralized knemidokoptic mange (Micnemidocoptes sp.) in a bald eagle (Haliaeetus leucocephalus) from Arkansas, USA.
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Southeastern Cooperative Wildlife Disease Study (SCWDS), Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA; Warnell School of Forestry and Natural Resources, University of Georgia, Athens, GA 30602, USA; Center for Ecology of Infectious Diseases, University of Georgia, Athens, GA 30602, USA. Electronic address:
This report describes a case of generalized knemidokoptic mange caused by Micnemidocoptes sp. in a bald eagle (Haliaeetus leucocephalus). In June 2024, an adult male eagle from Polk County, Arkansas, presented with severe skin disease and in a moribund state.
View Article and Find Full Text PDFSkin Grafting.
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Helsinki Burn Centre, Department of Plastic Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Although skin grafting is a basic surgical procedure, there are many sophisticated innovations that are used only by experienced surgeons. In-depth knowledge of new and old methods gives the opportunity to select the most appropriate technique in each case. Most methods have been invented long ago, but some of them have been rediscovered and further refined.
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