The authors hypothesized that older depressed patients would perform more poorly on the Ascending Digits Task (ADT) when matched against a nondepressed elderly comparison group. In a novel measure, the ADT, 129 older depressives scored more poorly than 129 comparison subjects in bivariate analyses and models controlling for demographic variables. The ADT may be a good measure of executive function in older adults.
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Detecting early cognitive deficits in preclinical Alzheimer's disease using a remote digital multi-day learning paradigm.
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Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02129, USA.
Remote, digital cognitive testing on an individual's own device provides the opportunity to deploy previously understudied but promising cognitive paradigms in preclinical Alzheimer's disease (AD). The Boston Remote Assessment for NeuroCognitive Health (BRANCH) captures a personalized learning curve for the same information presented over seven consecutive days. Here, we examined BRANCH multi-day learning curves (MDLCs) in 167 cognitively unimpaired older adults (age = 74.
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Division of Injury Prevention, Centers for Disease Control and Prevention (CDC), National Center for Injury Prevention and Control (NCIPC), Atlanta, Georgia, USA.
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Public Health and Sport Sciences, Faculty of Health and Life Sciences, University of Exeter, St Luke's Campus, Exeter, EX1 2LU, UK.
Human proficiency for bipedal locomotion relies on the structure and function of our feet, including the interplay between active muscles and passive structures acting on the toes during the propulsive phase of gait. However, our understanding of the relative contributions of these different structures remains incomplete. We aimed to determine the distinct toe-flexion torque-angle relationships of the plantar intrinsic muscles (PIMs), extrinsic muscles and passive structures, therefore offering insight into their force-generating capabilities and importance for walking and running.
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Appl Physiol Nutr Metab
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Exercise Medicine Research Institute, Edith Cowan University, Australia.
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