Aims: Periconceptional folate supplementation prevents neural tube defects and possibly congenital heart defects (CHD) as well. The search for candidate genes involved in the folate metabolism includes the methylenetetrahydrofolate reductase (MTHFR) 677C > T polymorphism. We studied the association between MTHFR 677C > T variants and CHD risk. The interaction with periconceptional folate supplementation was also investigated.
Methods And Results: A case-control study and a family-based transmission disequilibrium test (TDT) were conducted to explore this association. In 133 triads, the TDT revealed no association of the fetal 677T allele with the development of a heart defect. In 158 mothers with a CHD-affected child, the maternal MTHFR 677CT and TT genotypes in combination with no use of periconceptional folate supplements were associated with, respectively, a three-fold (OR 3.3 95% CI 1.46-7.32) and six-fold (OR 6.3 95% CI 2.32-17.27) increased risk for conotruncal heart defects in offspring. In a case-only study, the interaction between periconceptional folate supplementation and maternal MTHFR genotype was significant (P = 0.012).
Conclusion: The maternal MTHFR 677C > T variants are a risk factor for CHD in offspring, confined to conotruncal heart defects. A gene-environment interaction between maternal MTFHR 677CT and TT genotypes with periconceptional folate supplementation was observed. These findings provide a mechanism of the protective role of folate and support the thesis that periconceptional folate supplementation might prevent CHD.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/eurheartj/ehi815 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Spatial Transcriptomics and Single-Nucleus Multi-Omics Analysis Revealing the Impact of High Maternal Folic Acid Supplementation on Offspring Brain Development.
Nutrients
November 2024
Epigenomics and Computational Biology Lab, Fralin Life Sciences Institute, Virginia Tech, Blacksburg, VA 24061, USA.
Folate, an essential vitamin B9, is crucial for diverse biological processes, including neurogenesis. Folic acid (FA) supplementation during pregnancy is a standard practice for preventing neural tube defects (NTDs). However, concerns are growing over the potential risks of excessive maternal FA intake.
View Article and Find Full Text PDFA Randomized Crossover Trial of Acceptability of Quadruple-Fortified Salt in Women and their Households in Southern India.
J Nutr
October 2024
Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States; Joan Klein Jacobs Center for Precision Nutrition and Health, Cornell University, Ithaca, NY, United States; Division of Epidemiology, Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, United States; Division of Nutrition, St. John's Research Institute, Bengaluru, Karnataka, India. Electronic address:
Background: Double-fortified salt (DFS; iron, iodine) improved iron status in randomized trials and was incorporated into India's social safety net programs, suggesting opportunities to address other micronutrient deficiencies.
Objectives: To evaluate the acceptability of quadruple-fortified salt (QFS; iron, iodine, folic acid, and vitamin B) in women and their households, using a randomized crossover trial design and triangle tests.
Methods: Women 18-49 y (n = 77) and their households were randomly assigned to receive QFS or DFS in a randomized crossover design over a 3-wk period (week 1: QFS/DFS, week 2: iodized salt, week 3: DFS/QFS).
Periconceptional Folic Acid Supplementation and Risks of Small and Large for Gestational Age at Birth: The Mediation Effects of Maternal Homocysteine Level during Pregnancy.
J Nutr
October 2024
Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, China. Electronic address:
Background: Periconceptional folic acid supplementation (FAS) is widely recommended. However, the role of periconceptional FAS on neonatal birth weight remains unclear.
Objectives: This study aimed to explore the independent effects of periconceptional FAS on risks of small for gestational age (SGA) and large for gestational age (LGA) and to test the potential mediation role of maternal homocysteine (Hcy) during pregnancy on the above significant associations.
[Expert consensus on major micronutrient supplementation during peri-conceptional period (2024)].
Zhonghua Fu Chan Ke Za Zhi
October 2024
Maternal Folic Acid and Dietary Folate Intake in Relation to Sex Ratio at Birth and Sex-Specific Birth Weight in China.
Nutrients
September 2024
Department of Epidemiology and Health Statistics, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China.
Article Synopsis
- Prenatal folic acid supplements are known to reduce neural tube defects, but their relationship with sex-specific birth outcomes remains uncertain.
- This study analyzed data from 7,318 infants and their mothers in Northwest China to explore how folic acid and dietary folate intake affect birth sex ratios and birth weights.
- Results showed no link between folic acid intake and male birth likelihood, but higher folate intake was associated with increased birth weights for both sexes.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!