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Complicated iatrogenic Cushing's syndrome induced by topical clobetasol propionate in a child with psoriasis: a case report and review of the literature.
J Med Case Rep
December 2024
School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Background: Long-term use of oral or parenteral corticosteroids is the most common cause of hypothalamic-pituitary-adrenal axis suppression and iatrogenic Cushing's syndrome. Still, iatrogenic Cushing's syndrome occurs rarely following the administration of topical corticosteroids.
Case Presentation: This case study discusses the misuse of a high-potency corticosteroid cream by an Iranian 5-year-old male with plaque-form psoriasis, resulting in Cushingoid symptoms including moon face, buffalo hump, red striae, and weight gain.
Malignant thyroid neoplasm with ectopic Cushing's syndrome.
BMJ Case Rep
December 2024
Endocrinology, PGIMER, Chandigarh, India.
An adult man in his 30s with newly diagnosed diabetes mellitus and hypertension presented with a 33 lb weight gain, generalised swelling and classic Cushingoid features, including proximal muscle weakness, easy bruisability, wide violaceous striae and a painless, progressively enlarging right-sided neck swelling over the past month. Physical examination revealed a 4×4 cm thyroid mass, facial plethora and dorsocervical fat pads. Laboratory investigations confirmed hypercortisolism with elevated cortisol and Adrenocorticotropic Hormone(ACTH), with non-suppression on dexamethasone suppression tests.
View Article and Find Full Text PDFArticle Synopsis
- - Striae distensae is a common skin condition, starting as reddish lines (striae rubra) that turn silvery-white (stria alba) over time and can occasionally lead to rare complications like bullous striae distensae.
- - The case of a 17-year-old female with nephrotic syndrome highlighted the development of abdominal fluid-filled lesions after long-term systemic glucocorticoid use, where physical exams showed translucent bullae over stretch marks.
- - A punch biopsy confirmed the diagnosis of bullous striae distensae, emphasizing the importance of recognizing this rare complication to avoid unnecessary treatments and better manage the patient's underlying condition.
Artri King-induced Hypothalamic-pituitary-adrenal Axis Disruption: A Report of 3 Cases.
JCEM Case Rep
January 2024
Department of Internal Medicine, Division of Endocrinology, Los Angeles General Medical Center, Los Angeles, CA, USA.
We present a case series of 3 patients who developed iatrogenic hypothalamic-pituitary-adrenal axis disruption while taking Artri King, an over-the-counter supplement marketed for joint pain that is reported to contain dexamethasone not listed on the supplement's label. Patient 1, a 58-year-old woman, presented with persistent hyponatremia, weight gain, proximal muscle weakness, dorsocervical fat pad, and new, red striae on her breast and abdomen in the setting of Artri King use. Her dexamethasone level was elevated (Table 1), confirming the suspicion of dexamethasone content in this supplement.
View Article and Find Full Text PDFA real-world study of low-dose thalidomide in severe erythema nodosum leprosum highlighting its mechanistic rationale in a resource-constrained target population.
Int J Dermatol
January 2023
Department of Pathology, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, New Delhi, India.
Background: Corticosteroids remain the main therapy in erythema nodosum leprosum (ENL), and long-term usage in chronic or recurrent ENL is a cause of significant morbidity and mortality. Thalidomide exerts dramatic effect in controlling ENL and helps reduce the dose of steroids, but the cost is a hindrance to its usage.
Methods: Patients of ENL (steroid naïve and steroid-dependent) were recruited over a 1-year period.
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