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Testing the Feasibility, Acceptability, and Potential Efficacy of an Innovative Digital Mental Health Care Delivery Model Designed to Increase Access to Care: Open Trial of the Digital Clinic.
JMIR Ment Health
January 2025
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Background: Mental health concerns have become increasingly prevalent; however, care remains inaccessible to many. While digital mental health interventions offer a promising solution, self-help and even coached apps have not fully addressed the challenge. There is now a growing interest in hybrid, or blended, care approaches that use apps as tools to augment, rather than to entirely guide, care.
View Article and Find Full Text PDFHelping authors produce FAIR taxonomic data: evaluation of an author-driven phenotype data production prototype.
Database (Oxford)
January 2025
Research and Development Centre, Agriculture and Agri-Food Canada, 960 Carling Avenue, Ottawa, ON CA K1A 0C6, Canada.
It is well-known that the use of vocabulary in phenotype treatments is often inconsistent. An earlier survey of biologists who create or use phenotypic characters revealed that this lack of standardization leads to ambiguities, frustrating both the consumers and producers of phenotypic data. Such ambiguities are challenging for biologists, and more so for Artificial Intelligence, to resolve.
View Article and Find Full Text PDFMechanisms for DNA Interplay in Eukaryotic Transcription Factors.
Annu Rev Biophys
January 2025
1CREST Center for Cellular and Biomolecular Machines, University of California, Merced, California, USA; email:
Like their prokaryotic counterparts, eukaryotic transcription factors must recognize specific DNA sites, search for them efficiently, and bind to them to help recruit or block the transcription machinery. For eukaryotic factors, however, the genetic signals are extremely complex and scattered over vast, multichromosome genomes, while the DNA interplay occurs in a varying landscape defined by chromatin remodeling events and epigenetic modifications. Eukaryotic factors are rich in intrinsically disordered regions and are also distinct in their recognition of short DNA motifs and utilization of open DNA interaction interfaces as ways to gain access to DNA on nucleosomes.
View Article and Find Full Text PDFACT-enhanced peer coaching for online ACT self-help: Feasibility and acceptability with college students.
J Am Coll Health
January 2025
Department of Psychology, Utah State University, Logan, Utah, USA.
This secondary analysis examined the feasibility and acceptability of a novel peer coaching model designed to improve adherence to an online self-help program based on Acceptance and Commitment Therapy (ACT), called ACT Guide. All participants ( = 152) and peer coaches were undergraduate students attending the same university. Participants were instructed to use ACT Guide for 10 wk and were randomly assigned to receive weekly peer coaching through either phone calls or text messaging.
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