In summary, chondroid syringoma is a rare sweat gland neoplasm characterized by its slow growth and unpredictable growth phase. When malignant, it has a significant potential for recurrence, metastases, and even death. Due to the rarity of this tumor, an accurate preoperative diagnosis is difficult. Therefore, it is important for the clinician to have a high degree of suspicion for chondroid syringoma when considering the differential diagnosis of solid cutaneous nodules. A patient has been presented with a chondroid syringoma with atypical features, but no unequivocal evidence of malignancy. This poses a therapeutic dilemma. At the present time, the best therapeutic option appears to be accurate diagnosis, wide local excision, and close follow-up. Further research will elucidate the role of adjunctive treatment modalities.
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Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
January 2025
Department of Otorhinolaryngology Head and Neck Surgery, Nasal Skull Base Surgery, the Affiliated Hospital of Qingdao University, Qingdao266000, China.
To analyze the clinical features of nasal pleomorphic adenoma and to share clinical insights into its diagnosis and treatment. This was a case series study. Clinical data of 12 patients with nasal pleomorphic adenoma, confirmed by histopathology, admitted to the Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Qingdao University from 2014 to 2023, were retrospectively analyzed.
View Article and Find Full Text PDFCase Rep Dent
January 2025
Department of Conservative Dentistry and Endodontics, College of Dental Surgery, B.P. Koirala Institute of Health Sciences, Dharan, Nepal.
Pleomorphic adenoma (PA), the most common salivary gland tumor, presents unique challenges due to its diverse clinicopathologic features. The objective of this case series is to highlight the implication of detailed histopathological examination to guide appropriate diagnosis. This study reviews 10 cases of PA diagnosed at B.
View Article and Find Full Text PDFCarcinoma ex pleomorphic adenomas are rare malignant tumors of the salivary glands, primarily seen in older adults. They originate from benign pleomorphic adenomas, are aggressive, and have poorer prognosis. This case documents an unusual presentation of a massive carcinoma ex pleomorphic adenoma.
View Article and Find Full Text PDFVirchows Arch
January 2025
Department of Pathology, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.
Pleomorphic adenoma (PA), the most prevalent salivary gland tumor, exhibits a diverse histological spectrum characterized by epithelial, myoepithelial, and mesenchymal patterns, and secretory products. However, a subset of PAs presents microscopic features suggestive of malignancy, leading to challenging and potentially significant diagnostic pitfalls. A comprehensive retrospective analysis was conducted on the Salivary Gland Tumor Registry, compiled by the authors.
View Article and Find Full Text PDFBMC Oral Health
January 2025
Department of Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Background: Aurora kinase A (AurkA) plays a vital role in mitosis and is therefore critical in tumors development and progression. There are a few studies on AurkA expression in salivary gland tumors. The aim of the present study was to evaluate the expression pattern of AurkA in the most common benign and malignant salivary gland tumors by immunohistochemistry.
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