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Assessing the relationship between wrist synovitis and anxiety: a study using clinical statistics and Mendelian randomization analysis.
J Orthop Surg Res
January 2025
Department of Sports Medicine, Wuxi 9th People's Hospital Affiliated to Soochow University, Wuxi, Jiangsu, China.
Background: Wrist synovitis often leads to persistent pain, swelling, and limited mobility, causing significant functional impairment and psychological distress, including anxiety. Although arthroscopic synovectomy can alleviate physical symptoms, whether it also improves anxiety and the causal relationship between synovitis and anxiety remains unclear.
Methods: A prospective study was conducted on 44 patients diagnosed with wrist synovitis who underwent arthroscopic synovectomy.
Acute systemic macrophage depletion in osteoarthritic mice alleviates pain-related behaviors and does not affect joint damage.
Arthritis Res Ther
December 2024
Department of Internal Medicine, Division of Rheumatology, Rush University Medical Center, Chicago, IL, USA.
Background: Osteoarthritis (OA) is a painful degenerative joint disease and a leading source of years lived with disability globally due to inadequate treatment options. Neuroimmune interactions reportedly contribute to OA pain pathogenesis. Notably, in rodents, macrophages in the DRG are associated with onset of persistent OA pain.
View Article and Find Full Text PDFSynovial sarcoma masquerading as juvenile idiopathic arthritis.
BMJ Case Rep
December 2024
Clinical Immunology and Rheumatology, King George's Medical University, Lucknow, Uttar Pradesh, India.
Article Synopsis
- An early adolescent girl experienced chronic monoarthritis and was initially misdiagnosed with skeletal tuberculosis, leading to ineffective treatment.
- As her condition worsened over four months, doctors suspected juvenile idiopathic arthritis but later found stronger signs of a serious issue after imaging showed synovitis and necrotising myositis.
- A biopsy ultimately confirmed she had synovial sarcoma with metastasis, and despite a timely diagnosis, she tragically passed away from the illness.
Ferroptosis in Osteoarthritis: Towards Novel Therapeutic Strategy.
Cell Prolif
December 2024
Department of Genetics and Cell Biology, School of Basic Medicine, Qingdao University, Qingdao, China.
Osteoarthritis (OA) is a chronic, degenerative joint disease primarily characterised by damage to the articular cartilage, synovitis and persistent pain, and has become one of the most common diseases worldwide. In OA cartilage, various forms of cell death have been identified, including apoptosis, necroptosis and autophagic cell death. Ever-growing observations indicate that ferroptosis, a newly-discovered iron-dependent form of regulated cell death, is detrimental to OA occurrence and progression.
View Article and Find Full Text PDFStabilization of the Thumb Carpometacarpal Joint Utilizing a Minimally Invasive Approach: A Novel Technique.
Tech Hand Up Extrem Surg
December 2024
Division of Hand & Upper Extremity Surgery, Department of Orthopaedic Surgery, Harvard Medical School.
Treatment of symptomatic thumb carpometacarpal (CMC) joint synovitis can be challenging. Surgical options in these patients are often limited due to the patient's youth and lack of arthrosis. One of the most commonly used techniques involves the use of the flexor carpi radialis to reconstruct the ligamentous complex of the thumb CMC joint.
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