Mass spectrometry has become increasingly important in amyloid research specifically in the mechanism of formation and characterization of fibrils. In this review we highlight key experiments that provide evidence for different conformations, interactions and unfolding intermediates in proteins associated with amyloid diseases.
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OzNOxESI: A Novel Mass Spectrometry Ion Chemistry for Elucidating Lipid Double-Bond Regioisomerism in Complex Mixtures.
Anal Chem
January 2025
Center for Translational Biomedical Research, University of North Carolina at Greensboro, Kannapolis, North Carolina 28081, United States.
Double bond (C═C) position isomerism in unsaturated lipids can indicate abnormal lipid metabolism and pathological conditions. Novel chemical derivatization and mass spectrometry-based techniques are under continuing development to provide more accurate elucidation of lipid structure in finer structural detail. Here, we introduce a new ion chemistry for annotating lipid C═C positions, which is highly efficient for liquid chromatography-mass spectrometry-based lipidomics.
View Article and Find Full Text PDFExploring the Key Indicators for Off-Flavor in Industrial Osmanthus Absolute through Sensomics and Chemometric Approaches.
J Agric Food Chem
January 2025
Zhengzhou Tobacco Research Institute of CNTC, Fengyang Street #2, Zhengzhou, Henan 450001, PR China.
The occurrence of off-flavor in osmanthus absolutes has emerged as a significant concern that could hinder its broad market acceptance and associated economic development. In this study, key off-flavor molecules in industrial osmanthus absolute were identified through sensomics and chemometric approaches. A group of 10 off-flavor (OF) samples, eliciting smoky/phenolic, sweaty/sour, and spicy odors, were compared with 10 pleasant aroma (PA) samples through various analyses, including overall aroma assessment, comprehensive chemical profiling, aroma extract dilution analysis (AEDA), and orthogonal partial least-squares-discriminant analysis (OPLS-DA).
View Article and Find Full Text PDFVolatile Organic Compounds Inside Homes Impacted by Smoke from the Marshall Fire.
ACS EST Air
January 2025
Department of Chemistry, University of Colorado Boulder, Boulder, Colorado 80309, United States.
Wildfires at the wildland-urban interface (WUI) have been increasing in frequency over recent decades due to increased human development and shifting climatic patterns. The work presented here focuses on the impacts of a WUI fire on indoor air using field measurements of volatile organic compounds (VOCs) by Proton-Transfer-Reaction Time-of-Flight Mass Spectrometry (PTR-TOF-MS). We found a slow decrease in VOC mixing ratios over the course of roughly 5 weeks starting 10 days after the fire, and those levels decreased to ∼20% of the initial indoor value on average.
View Article and Find Full Text PDFCalifornium-252 Plasma Desorption Mass Spectrometry as an Aid in the Synthesis of a Series of Adenosine and Xanthine Conjugates.
J Chem Soc Perkin 1
January 1986
National Heart, Lung and Blood Institute Bethesda, Maryland 20892.
Two series of biologically active purine derivatives have been analyzed using californium-252 plasma desorption mass spectrometry. The series of compounds are adenosine agonists ( -phenyladenosine derivatives) and antagonists (8-phenyl-1,3-dipropylxanthine derivatives) at extracellular purine receptors. Included are receptor probes synthesized through successive chain elongation reactions.
View Article and Find Full Text PDFGenetic analyses of very long-chain acyl-coenzyme A dehydrogenase deficiency: A case report with a novel ACADVL variant.
Mol Genet Metab Rep
March 2025
Newborn Screening Center, Xuzhou Maternity and Child Health Care Hospital, Xuzhou, China.
Background: Very long-chain acyl-coenzyme A dehydrogenase deficiency (VLCADD) is a rare autosomal recessive disease associated with variants in the gene.
Methods: In December 2021, a neonate with VLCADD was identified via newborn screening in Xuzhou, China. Genetic testing and genetic family verification were performed via high-throughput sequencing combined with Sanger sequencing.
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