New tumour testing methods can improve the accuracy of diagnosis.
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Two-Phase Extraction for Comprehensive Analysis of the Plant Metabolome by NMR.
Methods Mol Biol
January 2025
Grupo Metabolômica, Universidade Estadual do Norte Fluminense, Campos dos Goytacazes, RJ, Brazil.
Metabolomics is the area of research, which strives to obtain complete metabolic fingerprints, to detect differences between them and to provide hypothesis to explain those differences (Schripsema J, Dagnino D, Handbook of chemical and biological plant analytical methods. Wiley, New York, 2015). However, obtaining complete metabolic fingerprints is not an easy task.
View Article and Find Full Text PDFAnatomy-driven segmentation of parafoveal optical coherence tomography (OCT) measures may improve associations with clinical outcomes in multiple sclerosis.
J Neurol
January 2025
Jacobs Comprehensive MS Treatment and Research Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.
Background: Previous investigations on optical coherence tomography (OCT) in multiple sclerosis (MS) focused on generalizable macular and peri-papillary regions without considering the anatomic variations of the retinal layer thickness.
Objective: This study aimed to assess the utility of parafoveal retinal layer thickness measured by OCT, underscoring its relationships with clinical outcomes in MS.
Methods: In this cross-sectional study, 214 people with MS (pwMS) and 57 age- and sex-matched healthy controls (HCs) were enrolled.
Ultrasound-guided needle positioning confirmation with injection of saline solution for nodal dynamic contrast-enhanced MR-lymphangiography in pediatric patients.
Eur Radiol
January 2025
Division for Minimally-invasive Lymph Vessel Therapy, Department of Diagnostic and Interventional Radiology, University Hospital of Bonn, Bonn, Germany.
Purpose: To assess the success rate of confirmation of ultrasound-guided intranodal needle positioning by saline injection for dynamic contrast-enhanced magnetic resonance lymphangiography (DCMRL) in pediatric patients.
Material And Methods: Data from children undergoing nodal DCMRL after ultrasound-guided needle positioning into inguinal lymph nodes and validation of the needle position by injection of plain saline solution between 05/2020 and 12/2022 were reviewed. On injection of saline solution, adequate needle position was confirmed by lymph node distension without leakage.
Transferability of Single- and Cross-Tissue Transcriptome Imputation Models Across Ancestry Groups.
Genet Epidemiol
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Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, The University of Manchester, Manchester, UK.
Transcriptome-wide association studies (TWAS) investigate the links between genetically regulated gene expression and complex traits. TWAS involves imputing gene expression using expression quantitative trait loci (eQTL) as predictors and testing the association between the imputed expression and the trait. The effectiveness of TWAS depends on the accuracy of these imputation models, which require genotype and gene expression data from the same samples.
View Article and Find Full Text PDFTolane-Based Phosphino- and Arsino-Ruthenium Complexes in Three Different Oxidation States: Ru(I), Ru(II) and Ru(III).
Chemistry
January 2025
Heidelberg University, Anorganisch-Chemisches Institut, Im Neuenheimer Feld 276, 69120, Heidelberg, GERMANY.
Targeting Ru(III) and Ru(I) η2-alkyne species, 2,2'-(iPr2E)2-substituted diphenylacetylenes (1-E, E = P, As) were em-ployed for the pre-paration of [ECCE]-coordinated ruthenium com-plexes. The re-actions between 1-E and cis-(MeCN)2(COD)RuCl2 led to the required Ru(II) starting materials cis-[ECCE]RuCl2(MeCN) (3-E). Upon oxi-dation of 3-E with PhICl2, the Ru(III) target com-plexes [ECCE]RuCl3 (7-E) were detectable for E = P and E = As, but only the arsa-deriva-tive 7-As was obtained in a pure form, namely via oxi-da-tion of cis-[AsCCAs]RuCl2(THT) (THT = tetrahydrothiophene).
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