Neuronal nicotinic acetylcholine receptors (nAChRs) are involved in a number of functional processes, including cognition, learning and memory, and alterations in their expression and/or activity have been implicated in various neurological disorders such as Alzheimer's disease (AD), Parkinson's disease and schizophrenia. Epidemiological studies have shown that exposure to electromagnetic fields (EMF) may contribute to the pathogenesis of neurodegenerative diseases such as Alzheimer's disease. Given the role of nAChRs in physiological and pathological conditions, we wondered whether an extremely low-frequency electromagnetic field (ELF-EMF) may affect the expression of the molecules involved in neurodegenerative processes. In order to investigate this possibility, we studied the expression of alpha3, alpha5 and alpha7 nicotinic subunits upon exposure of the SH-SY5Y human neuroblastoma cell line to a 50 Hz power-line magnetic field in a "blind trial" system; various magnetic flux densities and exposure times were applied. Our studies show that the expression of some relevant components of the cholinergic nicotinic system, which is one of the most affected neurotransmission systems in AD, did not undergo any change at molecular level by environmental exposure to ELF-EMF.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.toxlet.2006.01.006 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Comparison of EEG Signal Spectral Characteristics Obtained with Consumer- and Research-Grade Devices.
Sensors (Basel)
December 2024
Abu Dhabi Maritime Academy, Abu Dhabi P.O. Box 54477, United Arab Emirates.
Electroencephalography (EEG) has emerged as a pivotal tool in both research and clinical practice due to its non-invasive nature, cost-effectiveness, and ability to provide real-time monitoring of brain activity. Wearable EEG technology opens new avenues for consumer applications, such as mental health monitoring, neurofeedback training, and brain-computer interfaces. However, there is still much to verify and re-examine regarding the functionality of these devices and the quality of the signal they capture, particularly as the field evolves rapidly.
View Article and Find Full Text PDFEffects of Extremely Low-Frequency Electromagnetic Field Treatment on ASD Symptoms in Children: A Pilot Study.
Brain Sci
December 2024
Leaps and Bounds Exceptional Services ABA (Applied Behaviour Analysis) Program, Leaps and Bounds Clinic, 13045 Jane Street, King City, ON L7B 1A3, Canada.
Background/objectives: Autism Spectrum Disorder (ASD) are neurodevelopmental disorders marked by challenges in social interaction, communication, and repetitive behaviors. People with ASD may exhibit repetitive behaviors, unique ways of learning, and different ways of interacting with the world. The term "spectrum" reflects the wide variability in how ASD manifests in individuals, including differences in abilities, symptoms, and support needs, and conditions characterized by difficulties in social interactions, communication, restricted interests, and repetitive behaviors.
View Article and Find Full Text PDFEffects of extremely low frequency magnetic fields on animal cancer and DNA damage: a systematic review and meta-analysis.
Prog Biophys Mol Biol
December 2024
Research Unit in Public Health, Epidemiology and Health Economics, University of Liège, Avenue Hippocrate, 13/B-23, B-4000 Liège, Belgium.
The objective of this systematic review and meta-analysis is to assess the carcinogenic effects of extremely low frequency magnetic fields (ELF-MF) by analyzing animal and comet assay studies. We have performed a global meta-analysis on all the animal studies on the relation between ELF-MF and cancer incidence and separate meta-analyses on the incidence of cancer, leukemia, lymphoma, breast cancer, brain cancer and DNA damage assessed with the comet assay. Of the 5145 references identified, 71 studies have been included in our systematic review and 22 studies in our meta-analyses.
View Article and Find Full Text PDF[Effects of cochlear implantation on vestibular function in patients with large vestibular aqueduct syndrome].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
January 2025
This study aimed to compare the effects of cochlear implantation（CI） on vestibular function in patients with large vestibular aqueduct syndrome（LVAS） and in patients with extremely severe deafness with normal inner ear structure. A total of 28 LVAS patients and 28 patients with normal inner ear structure who suffered from extremely severe deafness were selected. The parameters of caloric tests, bone conduction evoked cervical vestibular-evoked myogenic potentials（cVEMP）, bone conduction evoked ocular vestibular-evoked myogenic potentials（oVEMP） and video head impulse tests（v-HIT） were compared between the two groups before and after CI.
View Article and Find Full Text PDFThe V30 benchmark set for anharmonic vibrational frequencies of molecular dimers.
J Chem Phys
December 2024
Department of Chemistry, University of Graz, Heinrichstraße 28/IV, 8010 Graz, Austria.
Intermolecular vibrations are extremely challenging to describe but are the most crucial part for determining entropy and hence free energies and enable, for instance, the distinction between different crystal-packing arrangements of the same molecule via THz spectroscopy. Herein, we introduce a benchmark dataset-V30-containing 30 small molecular dimers with intermolecular interactions ranging from exclusively van der Waals dispersion to systems with hydrogen bonds. All the calculations are performed with the gold standard of quantum chemistry CCSD(T).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!