AI Article Synopsis
- Several studies since 1992 show a strong link between the DD genotype of the angiotensin 1-converting enzyme (ACE) gene and coronary artery disease (CAD) in certain populations.
- The authors examined the ACE gene I/D genotypes in a group of 102 CAD patients and 50 controls, confirming CAD through coronaroangiography.
- The study found a notable correlation between the DD-ACE genotype and increased CAD risk, even when patients with classic risk factors like obesity and hypertension were excluded.
Article Abstract
The results of several studies which have been published since 1992 evidence a significant correlation between DD genotype of angiotensin 1-converting enzyme (ACE) gene and development of coronary artery disease (CAD) in some populations. The authors of this article studied distribution of ACE gene I/D genotypes (II, ID, DD) in 102 patients with CAD and 50 controls without cardiovascular pathology or diabetes mellitus. The CAD diagnosis was confirmed by coronaroangiography. The study established a significant correlation between the presence of DD-ACE genotype and development of CAD. After exclusion of patients with classic risk factors (body mass index greater than 26 kg/m2; arterial hypertension; dislipidemia), this correlation remained. The results of the study demonstrate a significant positive correlation between the presence of DD genotype and high risk of CAD in this population, including people without such classic risk factors as obesity, arterial hypertension, or dislipidemia.
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