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Nanocarrier anticancer drug-conjugates cause higher cellular deformations: culpable for mischief.
Biomater Sci
October 2020
School of Pharmacy, Dr. Vishwanath Karad Maharashtra Institute of Technology-World Peace University, Kothrud, Pune 411038, India. and School of Consciousness, Dr. Vishwanath Karad Maharashtra Institute of Technology-World Peace University, Kothrud, Pune 411038, India.
Here we report nanocarrier-anticancer drug conjugates culpable for cellular deformations, critically evidenced through image-based analysis as a measure of karyoplasmic ratio (KR) and nuclear surface area (NSA). Multiwalled carbon nanotubes (MWCNTs) were coordinated additionally with Fe3O4 nanoparticles (NPs) to evaluate the symbiotic influence, and further conjugated to Dox for evaluating the cellular kinetics and for measuring cell deformations. Cellular entry kinetics of the CNT (CNT-Dox and CNT-Cys-Fe3O4-Dox) nanocarriers and their efficiency in nuclear localization were evaluated using cervical cancer (HeLa) cells.
View Article and Find Full Text PDFThe reductive hotspot hypothesis of mammalian aging: membrane metabolism magnifies mutant mitochondrial mischief.
Eur J Biochem
April 2002
Department of Genetics, University of Cambridge, UK.
A severe challenge to the idea that mitochondrial DNA mutations play a major role in the aging process in mammals is that clear loss-of-function mutations accumulate only to very low levels (under 1% of total) in almost any tissue, even by very old age. Their accumulation is punctate: some cells become nearly devoid of wild-type mitochondrial DNA and exhibit no activity for the partly mitochondrially encoded enzyme cytochrome c oxidase. Such cells accumulate in number with aging, suggesting that they survive indefinitely, which is itself paradoxical.
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Clin Nucl Med
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Department of Radiology, University of Pittsburgh School of Medicine, Pennsylvania.
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