The aim of the study was to compare the serum levels of interferon-gamma (INF-gamma ) and neopterin (NPT) in 20 patients with chronic periodontitis and the control group (10 blood donors). We also investigated the difference between the mild (I group) and moderate forms (II group) of chronic periodontitis. Each group consisted of 10 patients. The serum levels of INF-gamma and NPT were measured using enzyme immunoassay techniques. The mean serum INF-gamma level in control was 9.7+/-3.18 pg/mL. The mean serum INF-gamma level in chronic periodontitis patients (n=20) was 13.08+/-4.6 pg/mL, in the I group (n=10) it was equal to 12.09+/-4.8 pg/mL; in the II group (n=10) - 13.2+/-4.03 pg/mL. Serum levels of INF-gamma in patients with chronic periodontitis were significantly higher than those in controls (p=0,024). Significant difference was observed in serum levels of INF-gamma between patients with moderate form and control group (p=0,043). There was no significant difference in serum levels of INF-gamma between patients with mild form and the control group (p=0,11). There was no significant difference between patients from I and II groups (p=0.9). The mean serum level of NPT in the control was 5.3+/-2.39 nmol/L. The mean serum NPT level in patients (n=20) with chronic periodontitis was 11.83+/-7.5 nmol/L, in I group it was equal to 9.27+/-1.84 nmol/L; in the II group -- 14.4+/-10.05 nmol/L. Serum levels of NTP in patients with chronic periodontitis were significantly higher than those in controls (p=0.001). Significant difference was observed in serum levels of NPT between patients with mild form and control group (p=0.0006). There was significant difference in serum levels of NPT between patients with moderate form and the control group (p=0.02). There was no significant difference between patients from the I and II groups (p=0.13).
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Evaluation of the association between thyroid-stimulating hormone with handgrip strength and dynapenia in euthyroid postmenopausal women.
Menopause
January 2025
From the Department of Obstetrics, Gynecology and Reproduction, Dexeus University Hospital, Barcelona, Spain.
Objective: To examine the association between serum thyroid-stimulating hormone (TSH) levels with handgrip strength (HGS) and dynapenia in euthyroid postmenopausal women.
Methods: This was an exploratory cross-sectional study among 385 participants from the Department of Obstetrics, Gynecology, and Reproduction of the Dexeus Women's University Hospital, Barcelona, Spain. Age, age at menopause, adiposity, alcohol consumption, body mass index (BMI), and smoking status were recorded.
Deubiquitinating enzyme USP2 alleviates muscle atrophy by stabilizing PPARγ.
Diabetes
January 2025
Department of Geriatrics, Peking University Shenzhen Hospital, Shenzhen, China.
Insulin resistance, a hallmark of type 2 diabetes, accelerates muscle breakdown and impairs energy metabolism. However, the role of Ubiquitin Specific Peptidase 2 (USP2), a key regulator of insulin resistance, in sarcopenia remains unclear. Peroxisome proliferator activated receptor γ (PPARγ) plays a critical role in regulating muscle atrophy.
View Article and Find Full Text PDFDapagliflozin inhibits ferroptosis to improve chronic heart failure by regulating Nrf2/HO-1/GPX4 signaling pathway.
PLoS One
January 2025
Hebei General Hospital, Shijiazhuang City, Hebei Province, P.R. China.
Objective: To study the effect of Dapagliflozin on ferroptosis in rabbits with chronic heart failure and to reveal its possible mechanism.
Methods: Nine healthy adult male New Zealand white rabbits were randomly divided into Sham group (only thorax opening was performed in Sham group, no ascending aorta circumferential ligation was performed), Heart failure group (HF group, ascending aorta circumferential ligation was performed in HF group to establish the animal model of heart failure), and Dapagliflozin group (DAPA group, after the rabbit chronic heart failure model was successfully made in DAPA group). Dapagliflozin was given by force-feeding method.
Objective: Aim: To investigate the effect of succinic acid on the humoral component of the immune system in rats.
Patients And Methods: Materials and Methods: The study was conducted on two groups of mature non-linear white rats (males) of similar weight (200-270 g, aged 6-8 months), with 5 animals in each group. The control group was fed a standard diet with free access to water throughout the experiment.
Objective: Aim: To investigate the peculiarities of deviations of preoperative values of biochemical markers of inflammation in the blood serum of patients with degenerative diseases of the lumbar spine after transpedicular fixation, with a complicated postoperative course to predict the development of various postoperative complications.
Patients And Methods: Materials and Methods: The content of glycoproteins (GP), sialic acids (SA), C-reactive protein (CRP), seroglicoids (SG), haptoglobin (HG), Veltman`s test (VT) were investigated. The results are comparable by the Student-Fisher method.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!