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Obesity and fibromyalgia are associated with Difficult-to-Treat Rheumatoid Arthritis (D2T-RA) independent of age and gender.
Arthritis Res Ther
January 2025
Department of Biomedical Sciences, Humanitas University, Via R Levi Montalcini 4, Pieve Emanuele, Milan, 20090, Italy.
Background: There is still a significant proportion of patients with rheumatoid arthritis (RA) in whom multiple therapeutic lines are ineffective. These cases are defined by the EULAR criteria as Difficult-to-Treat RA (D2T-RA) for which there is limited knowledge of predisposing factors.
Objective: To identify the clinical features associated with D2T-RA in real-life practice.
Conformational Plasticity and Binding Affinity Enhancement Controlled by Linker Derivatization in Macrocycles.
Angew Chem Int Ed Engl
January 2025
Darmstadt University of Technology: Technische Universitat Darmstadt, Clemens-Schöpf-Institute of Organic Chemistry and Biochemistry, Alarich-Weiss-Strasse 4, 64287, Darmstadt, GERMANY.
Macrocycles are abundantly used by nature to enable cell-permeable bioactive molecules. Synthetic non-peptidic macrocycles are also increasingly considered as modalities for difficult-to-bind proteins but guidelines for macrocyclization are only beginning to emerge. Macrocycles are thought to constrain the available conformations but also to allow for residual flexibility, the latter being poorly understood.
View Article and Find Full Text PDFRandomized control trial to compare mini-PCNL vs standard-PCNL for treatment of 1-2 cm size inferior calyceal renal stone.
Med J Armed Forces India
December 2024
CSO Medical, Andaman & Nicobar Command HQ, India.
Background: Lower calyceal anatomy makes the stone clearance a difficult task across all treatment formats. Improvement in optics and miniaturization of instruments have offered an effective and safer alternative to percutaneous nephrolithotomy (PCNL). The study was conducted to compare the efficacy and complications associated with mini-PCNL vs standard-PCNL.
View Article and Find Full Text PDFDietary fiber influence on overall health, with an emphasis on CVD, diabetes, obesity, colon cancer, and inflammation.
Front Nutr
December 2024
Department of Community Health, College of Applied Medical Sciences, Northern Border University, Arar, Saudi Arabia.
Dietary fiber, found in plant-based foods, plays an essential role in human health. It is divided into two types-soluble and insoluble-both offering significant health benefits. Research has shown that increasing fiber intake can reduce the risk of various chronic diseases, such as cardiovascular diseases (CVD), type II diabetes, obesity, colon cancer, and inflammation.
View Article and Find Full Text PDFAn overview of the nutritional quality and health benefits linked to the world diversity of citrus fruits/juices.
J Food Sci
December 2024
QualiSud, Univ. Montpellier, CIRAD, Institut Agro, Université d'Avignon, Université de La Réunion, Montpellier, France.
Citrus juices represent a nutrient-dense beverage due to the remarkable balance in their bioactive compounds (vitamins, minerals, dietary fibers, and phytochemicals such as flavonoids and carotenoids). This review aims to examine the nutritional quality and the health benefits of citrus juice consumption linked to the world diversity of citrus fruits. This work provides heterogenous data found on the main citrus bioactive compounds, especially carotenoids and flavonoids, which are difficult to correlate to particular geographic areas.
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