About 1 in 5 sexually active adults in the United States has serologic evidence of genital herpes caused by herpes simplex virus type-2. Neonatal herpes simplex virus infection is a serious consequence of genital herpes infection. Herpes infection in neonates causes significant morbidity and neurologic damage and generally has a case-fatality ratio untreated of 60%. It is estimated that 440 to 1,320 cases of neonatal herpes infections occur in the United States per year (11-33 cases occur per 100,000 live births). Given the challenges in surveillance for genital herpes due to the large number of asymptomatic infections and infrequent laboratory-based diagnosis, we recommend that to begin an effective national control program for herpes infections, a mandatory national surveillance system for neonatal herpes be implemented. Such a system would help assure appropriate therapy, help monitor trends and understand the burden of disease, identify risk determinants, and evaluate prevention efforts.
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| http://dx.doi.org/10.1097/01.olq.0000187203.27918.45 | DOI Listing |
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Proteomic profiling of neonatal herpes simplex virus infection on dried blood spots.
Commun Med (Lond)
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Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
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Estimated global and regional economic burden of genital herpes simplex virus infection among 15-49 year-olds in 2016.
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Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva, Switzerland.
Background: Globally, herpes simplex virus (HSV)-2 and -1 infections contribute to a large disease burden, but their full economic consequences remain unclear. This study aims to estimate the global economic impact of genital HSV-2 and HSV-1 infection and its consequences for people with genital ulcer disease, neonatal herpes, and human immunodeficiency virus (HIV) infection attributable to HSV-2.
Methods: Using a societal perspective, the economic burden was calculated at the country level and presented by World Health Organization (WHO) regions and World-Bank income levels.
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- The results showed an NHSV incidence of 5.9 per 100,000 live births, with notable demographics suggesting that horizontal transmission was linked to practices like ritual circumcision.
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Japanese Foundation for Sexual Health Medicine, Tokyo, Japan.
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