Our recent findings suggest that bacteriophages (phages) may not only eliminate bacteria, but also modulate immune functions. In this communication, we demonstrate that phages may strongly inhibit human T-cell activation and proliferation as well as activation of the nuclear transcription factor NF-kappaB in response to a viral pathogen. Phage administration in vivo can diminish cellular infiltration of allogeneic skin allografts. Thus, phage treatment should be considered in antibiotic-resistant posttransplantation infections. Furthermore, phages could find a broader application in clinical transplantation.
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| http://dx.doi.org/10.1016/j.transproceed.2005.12.073 | DOI Listing |
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- * Chronic wounds particularly affect elderly and diabetic patients, often requiring repeated medical interventions to avoid complications like infections that can have severe local and systemic effects.
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