3-[6-(2-Dimethylamino-1-imidazol-1-yl-butyl)-naphthalen-2-yloxy]-2,2-dimethyl-propionic acid and analogs were designed and synthesized as highly potent and selective CYP26 inhibitors, serving as retinoic acid metabolic blocking agents (RAMBAs), with demonstrated in vivo efficacy to increase the half-life of exogenous atRA.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2006.02.020 | DOI Listing |
Publication Analysis
Top Keywords
3-[6-2-dimethylamino-1-imidazol-1-yl-butyl-naphthalen-2-yloxy]-22-dimethyl-propionic acid
8
highly potent
8
potent selective
8
retinoic acid
8
acid metabolic
8
metabolic blocking
8
acid highly
4
selective retinoic
4
blocking agent
4
agent 3-[6-2-dimethylamino-1-imidazol-1-yl-butyl-naphthalen-2-yloxy]-22-dimethyl-propionic
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!