AI Article Synopsis
- The study aimed to investigate the effects of the Chinese herbal medicine Selaginella on enhancing the effectiveness of radiotherapy for terminal nasopharyngeal carcinoma (NPC).
- 180 NPC patients were split into three groups: one received only radiotherapy, the second had daily Selaginella during treatment, and the third had it later in the course.
- Results showed that groups receiving Selaginella had higher complete remission rates for both primary lesions and cervical lymph nodes, and the acute side effects were milder, suggesting Selaginella enhances radiotherapy without raising toxicity.
Article Abstract
Objective: To observe the Chinese herbal medicine Selaginella-induced radiosensitization of terminal nasopharyngeal carcinoma (NPC).
Methods: Totally 180 patients with NPC were divided equally into 3 groups with the same radiotherapeutic protocols. The patients in group A received radiotherapy alone, those in group B were given daily Selaginella (30 g) prepared into 50 ml decoction during the entire course of radiotherapy, and those in group C had Selaginella 30 g daily in the late course of radiotherapy.
Results: The complete remission rate of nasopharyngeal primary lesions in groups B and C was significantly higher than that in group A, with also significantly higher complete remission rates of the cervical lymph nodes. The acute toxicity of the skin and mucous membrane was milder in the latter two groups, but the differences were not significant.
Conclusion: Selaginella may induce radiosensitization for terminal NPC and does not increase the acute toxicity of radiotherapy.
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