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Structural and Functional Projections of the Nucleus Basalis of Meynert and Their Changes After Cognitive Training in Individuals With Mild Cognitive Impairment.
CNS Neurosci Ther
December 2024
Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China.
Aims: The nucleus basalis of Meynert (NBM) is a major source of cholinergic innervation in the central nervous system. We aimed to investigate the characteristics of structural and functional alterations in the NBM and its projections in patients with mild cognitive impairment (MCI) and the effects of computerized cognitive training (CCT).
Methods: Forty-five patients with MCI and 45 cognitively unimpaired controls (CUCs) were recruited.
CT- and MRI-based Factors Associated with Rapid Growth in Early-Stage Hepatocellular Carcinoma.
Radiology
December 2024
From the Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic-ro 43 gil, Songpa-Gu, Seoul 05505, Korea (H.J.J., S.H.C., S.J.C., J.H.B., H.J.W., Y.M.S.); University of Ulsan College of Medicine, Seoul, Korea (S.W.); and Liver Imaging Group, Department of Radiology, University of California- San Diego, San Diego, Calif (C.B.S.).
Background Prediction of the tumor growth rates is clinically important in patients with hepatocellular carcinoma (HCC), but previous studies have presented conflicting results and generally lacked radiologic evaluations. Purpose To evaluate the percentage of rapidly growing early-stage HCCs in each Liver Imaging Reporting and Data System (LI-RADS) category and to identify prognostic factors associated with rapid growth. Materials and Methods Retrospective study of patients with risk factors for HCC and those with surgically proven early-stage HCC who underwent two or more preoperative multiphasic CT or MRI examinations between January 2016 and December 2020.
View Article and Find Full Text PDFAn open data for imaging acute aerobic exercise effects on brain and mind in emerging adulthood.
Sci Data
December 2024
CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, 100101, China.
How emerging adulthood, a period particularly susceptible to the onset of mental disorders, responds to acute aerobic exercise effects on mood and brain remains an open question. A challenge in addressing this question is the scarcity of open data derived from scientific intervention paradigms. We recruited 83 healthy volunteers aged 17 to 24, who were randomly assigned to either an exercise group or a control group.
View Article and Find Full Text PDFHydroxyl groups introducing NMR strategy for structural elucidation of a heptasaccharide isolated from Trillium tschonoskii.
Carbohydr Res
December 2024
Beijing Institute of Radiation Medicine, Beijing, 100850, China; Shandong University of Traditional Chinese Medicine, Jinan, 250355, China. Electronic address:
A heptasaccharide was isolated from an active fraction of Trillium tschonoskii using HILIC and high-temperature PGC chromatography methods. UHPLC-Q/TOF-MS analysis gave this oligosaccharide a degree of polymerization (DP) of 7 and MS/MS showed that it has a six-carbon aldehyde glucan structure with the possible chain 1 → 4 connected. The structure was determined by series 1D and 2D NMR in two solvents DO and DMSO‑d.
View Article and Find Full Text PDFPI-RADS in Predicting csPCa: A Comparison Between Academic and Nonacademic Centers.
Prostate
December 2024
Urology Unit, Department of Medical, Oral and Biotechnological Sciences, 'G. d'Annunzio University', Chieti, Italy.
Introduction: The introduction of multiparametric prostate magnetic resonance imaging (mpMRI) has revolutionized prostate cancer (PCa) diagnosis, enhancing the localization of clinically significant prostate cancer (csPCa) and guiding targeted biopsies. However, significant disparities in the execution, interpretation, and reporting of prostate MRI examinations across centers necessitate greater standardization and accuracy. This study compares the diagnostic efficacy of mpMRI from academic and nonacademic centers in detecting csPCa and identifies factors associated with csPCa detection.
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