On the basis of evidence collected from the literature, we propose a general model by which protein kinase (PK) A and the different PKC isoforms can inversely affect cell growth. Molecular switches, which are able to direct the signal towards antiproliferative or mitogenic pathways, are the different isoforms of Raf and PKC. Conflicting data are also reported and discussed in an attempt to reconcile them.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11136383 | PMC |
| http://dx.doi.org/10.1007/s00018-005-5541-1 | DOI Listing |
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