The city of Campinas is located in an endemic area for Brazilian spotted fever in São Paulo State, where several cases have recently occurred. Capybaras have been associated with the cycle of this disease, for they present positive serology and serve as host for ticks of the genus Amblyomma, the main vectors of Brazilian spotted fever. Ticks were collected both from Capybaras and from the vegetation in the city park Lago do Café, located in the urban area of Campinas City, SP, a site associated with suspected human cases of Brazilian spotted fever. The ticks collected were examinated for the presence of rickettsiae using polymerase chain reaction and the haemolymph test. Through analysis of the gene gltA nucleotide sequence, adults of Amblyomma cajennense and Amblyomma cooperi were found to be infected with the non pathogenic Rickettsia bellii. However, no rickettsiae of the Spotted Fever Group were detected. These results indicate that the role of capybaras as reservoirs of rickettsiae of the Spotted Fever Group is still uncertain and further studies are required.
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http://dx.doi.org/10.1590/s0037-86822006000100013 | DOI Listing |
Cureus
December 2024
Department of Microbiology, All India Institute of Medical Sciences, New Delhi, New Delhi, IND.
Background: Tick-borne diseases (TBDs) play a crucial role in human morbidity and mortality, as ticks are highly effective in spreading diseases by transmitting harmful pathogens to humans and animals. The last few decades have seen an increase in the number of recognized tick-borne pathogens and the incidence of TBD worldwide. Several of these diseases are ubiquitous in India.
View Article and Find Full Text PDFTicks Tick Borne Dis
January 2025
Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA USA. Electronic address:
Rickettsiae are a family of ectoparasite-borne bacteria that can produce high morbidity and mortality among humans. There are scarce data on rickettsial ecology in rural areas of the Peruvian Amazon basin, where seroprevalence has not been determined, and the identities of animals acting as reservoirs of these bacteria are not known. We conducted a cross-sectional study in Zungarococha (between 2019 and 2021), a rural community located approximately 20 km away from Iquitos city.
View Article and Find Full Text PDFPathogens
December 2024
Centro di Referenza Nazionale per Anaplasma, Babesia Rickettsia, e Theileria (C.R.A.Ba.R.T.), Istituto Zooprofilattico Sperimentale della Sicilia "A. Mirri", 90129 Palermo, Italy.
Vector-borne diseases represent a serious threat to human and animal health, especially where environmental conditions favor pathogen-carrying vectors. Dogs serve as natural hosts for two tick-borne pathogens: , which causes canine monocytic ehrlichiosis, and spotted fever group (SFG) spp., a zoonotic threat in the Mediterranean region.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Biochemistry, Bahauddin Zakariya University, Multan, 66000, Punjab, Pakistan.
Rocky Mountain Spotted Fever, caused by the gram-negative intracellular bacteria Rickettsia rickettsii, is a serious tick-borne infection with a fatality rate of 20-30%, if not treated. Since it is the most serious rickettsial disease in North America, modified prevention and treatment strategies are of critical importance. In order to find new therapeutic targets and create multiepitope vaccines, this study integrated subtractive proteomics with reverse vaccinology.
View Article and Find Full Text PDFActa Trop
January 2025
Professor, Department of Paediatrics, All India Institute of Medical Sciences [AIIMS], Bhubaneswar 751019, Odisha, India. Electronic address:
Spotted fever group Rickettsia (SFGR) infections remain largely under-investigated as causative agents of acute undifferentiated febrile illness (AUFI) in resource-limited settings. Few studies are available on the prevalence of SFGR infections in India, especially in eastern India. In a cross-sectional study conducted in 192 hospitalized adult and paediatric patients with AUFI, the frequency of SFGR using sequential PCR targeting genes encoding citrate synthase (gltA), 17 kDa lipoprotein precursor antigen (17kDa), outer membrane proteins A and B (omp A & omp B) was 6.
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