AI Article Synopsis
- The study investigates the relationship between lymphocyte G-protein coupled receptor kinase (GRK) mRNA expression and the severity of congestive heart failure (CHF).
- In a sample of 15 CHF patients, those in higher severity classes (III) had significantly higher GRK mRNA levels compared to lower severity patients (IIA).
- The findings suggest that GRK expression could be a biological marker for CHF severity, and that treatment with angiotensin converting enzyme inhibitors (ACEI) may help lower GRK levels in patients.
Article Abstract
Background: There are few biological markers, which strictly show the severity of congestive heart failure (CHF).
Methods And Results: Lymphocyte G-protein coupled receptor kinase (GRK) mRNA expression was measured by quantitative reverse transcription-polymerase chain reaction in 15 CHF patients: 5 patients classified as New York Heart Association class-II treated with angiotensin converting enzyme inhibitor (ACEI) (IIA), 5 patients in class-II without ACEI (IIC), and 5 patients in class-III treated with ACEI (IIIA). GRK mRNA level in IIIA was significantly higher than those in IIA (p<0.05). GRK mRNA level in IIA were significantly lower than those in IIC (p<0.05).
Conclusions: The expression level of lymphocyte GRK might show the severity of CHF, and ACEI treatment could reduce the level of GRK in CHF patients.
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| http://dx.doi.org/10.1253/circj.70.362 | DOI Listing |
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