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Reactivation of severe, acute pulmonary tuberculosis during treatment with pegylated interferon-alpha and ribavirin for chronic HCV hepatitis. | LitMetric

AI Article Synopsis

  • The observation of severe pulmonary tuberculosis in a patient after 7 months of treatment for chronic hepatitis C raised concerns about potential immune system issues.
  • The patient's past chest radiograph suggested a possible prior infection with tuberculosis that went unnoticed.
  • This highlights the need for careful screening for latent tuberculosis in patients receiving immunomodulatory treatments like interferon to prevent reactivation.

Article Abstract

The unexpected observation of severe pulmonary tuberculosis after a 7-month combined pegylated interferon-ribavirin for chronic hepatitis C, prompted us to search an eventual immunodeficiency (lymphopenia and/or depletion of CD4+ T-lymphocytes. The retrieval of a chest radiograph incidentally performed 11 y before and showing a probable primary tuberculosis, paralleled a negligible clinical history. The enlargement of interferon indications needs careful evaluation for prior (usually missed) tuberculosis, to prevent or avoid its possible reactivation. Latent tuberculosis is increasingly reported because of extended life expectancy, immigration, and recent availability of cure for multiple chronic disorders, which are often borne by primary-secondary immunodeficiency.

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Source
http://dx.doi.org/10.1080/00365540500263268DOI Listing

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