Described is a computer-assisted rational design of a DNA-bis-intercalator peptide library. The peptide library of 250 members was prepared and the most powerful binder identified. A value of the binding constant is almost two orders of magnitude higher than that of starting building block-9-aminoacridine. The binder affinity found toward calf thymus DNA is 30-fold of that of human prion peptide 106-126.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/bip.20487 | DOI Listing |
Publication Analysis
Top Keywords
rational design
8
peptide library
8
design synthesis
4
synthesis double-stranded
4
double-stranded dna-binder
4
dna-binder library
4
library described
4
described computer-assisted
4
computer-assisted rational
4
design dna-bis-intercalator
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!