Several aspects of the manufacture of nanospheres containing metronidazole were studied. Nanospheres made of amphiphilic beta-cyclodextrin containing metronidazole were prepared by adding an acetone solution of amphiphilic cyclodextrin to an aqueous solution of metronidazole with or without Pluronic PE/F68 as the surfactant. An optimized formulation with high encapsulation efficiencies and with an appropriate particle size for intravenous administration, was developed. The entrapment of metronidazole was strongly dependent of the method of preparation and drug concentrations. These nanospheres prepared by nanocrystallization are promising carriers for metronidazole in the treatment of hepatic abscess.
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