AI Article Synopsis
- A study examined the antibody response in 86 volunteers who received six doses of the anthrax vaccine (AVA), showing that 93% developed protective antibodies after the second dose and 100% after the third.
- The geometric mean concentrations (GMC) of antibodies were lower after the third dose compared to the subsequent doses, indicating a drop in antibody levels before the next boosts.
- The decay rate of antibodies was significantly faster after the third dose, suggesting that the sixth dose is crucial for maintaining high levels of protective antibodies over time.
Article Abstract
The antibody profile during and after the six-dose primary vaccination series with anthrax vaccine adsorbed (AVA, Biothrax) was characterized in 86 human volunteers. Ninety-three percent of recipients developed IgG antibodies to Bacillus anthracis protective antigen (PA) after two doses, and 100% were seropositive after dose #3. Geometric mean concentrations (GMC) of IgG to PA measured before and after each dose were significantly lower after injection #3 (peak GMC=146.65 microg/mL, trough GMC=15.16 microg/mL) than after injections #4 (peak GMC=430.46 microg/mL, trough GMC=94.57 microg/mL), #5 (peak GMC=415.05 microg/mL, trough GMC=81.94 microg/mL), or #6 (peak GMC=401.16 microg/mL, trough GMC=96.19 microg/mL) (p
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http://dx.doi.org/10.1016/j.vaccine.2006.01.054 DOI Listing Publication Analysis
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