[Evaluation of the treatment with disodium cromoglycate in the ulcerative rectocolitis. Our experience].

Background And Aims: This study highlights the possibility of treating recidivating ulcerative rectocolitis with oral disodium cromoglycate based on the assay of plasma IgE.

Methods: The study was performed from January 1995 to December 1997 in 28 patients suffering from recidivating ulcerative rectocolitis whose main symptom was hematic diarrhoea. Total plasma IgE were assayed in all patients and oral disodium cromoglycate treatment was commenced at a dose of 1.500 mg pro/die with follow-up at 2, 6, 12 and 24 months to evaluate general and endoscopic clinical conditions.

Results: Patients with a high titre of total IgE showed a full remission of symptoms and no recidivation.

Conclusions: The authors conclude by emphasising the importance of immunological factors in the pathogenesis of the disease and underline the stabilising effect of oral disodium cromoglycate on mast cells.