Objective: To observe the changes in gene expression of cyclooxygenase (COX) during spontaneous recovery from stress ulcer in rats exposed to water immersion and restraint stress (WRS).
Methods: A rat model of stress ulcer was established by means of WRS, in which the changes in COX expression were detected with immunohistochemistry and reverse transcription (RT)-PCR.
Results: Very low levels of COX-2 expression were detected in the gastric mucosa of the control rats, and the expression increased significantly during the healing process of the stress ulcer (P<0.05). COX-1 expression in the gastric mucosa showed no significant difference between the control group and the stress ulcer groups during healing (P>0.05).
Conclusion: COX-1 and COX-2 expressions in rat gastric mucosa during the recovery from stress ulcer participate in the recovery of the damaged mucosa possibly by mediating prostaglandin secretion.
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Naunyn Schmiedebergs Arch Pharmacol
January 2025
The First Clinical College of Medicine, Fujian Medical University, Fuzhou, 350005, China.
Ulcerative colitis (UC) remains an intractable and relapsing disease featured by intestinal inflammation. The anti-UC activity of Akkermansia muciniphila (AKK), an intestinal microorganism, has been widely investigated. The current work is to explore the impacts of AKK on UC and its possible reaction mechanism.
View Article and Find Full Text PDFFront Pharmacol
January 2025
Department of Pharmacy, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Introduction: Preventive drugs for stress ulcers are widely and unreasonably used in the Intensive Care Unit (ICU). This study aims to examine the appropriate utilization of medications for stress ulcer prophylaxis (SUP) and identify factors that contribute to the inappropriate use of these medications in the ICU of the Second Hospital of Shanxi Medical University.
Methods: Patient cases admitted to the ICU during the period from May 2022 to May 2023 were extracted from the hospital's information management system.
Mitochondria are important organelles that regulate cellular energy and biosynthesis, as well as maintain the body's response to environmental stress. Their dynamics and autophagy influence occurrence of cellular function, particularly under stressful conditions. They can generate reactive oxygen species (ROS) which is a major contributor to inflammatory diseases such as ulcerative colitis (UC).
View Article and Find Full Text PDFBiomed Pharmacother
January 2025
Department of Gastroenterology, Nanjing Drum Tower Hospital, Nanjing, China. Electronic address:
Gastric ulcer (GU), a common digestive system disorder in clinical practice, often arises from excessive alcohol consumption and other factors that irritate the gastric mucosa. Effective treatment of GU remains challenging due to the poor targeting, limited efficacy, and significant side effects associated with current therapeutic approaches. To address these limitations, we developed a microenvironment-responsive hydrogel composed of sodium alginate (SA) and chitosan (CS), incorporating MnO nanoparticles and pachymic acid (PA).
View Article and Find Full Text PDFNaunyn Schmiedebergs Arch Pharmacol
January 2025
Department of Dermatology, Dongshan Hospital, Guofengyuan Building, Xuezi Avenue, Meijiang District, Meizhou, 514011, Guangdong, China.
Platelet-rich plasma (PRP) holds promising prospects for the treatment of skin photoaging. This study aims to unravel the mechanism underlying PRP's anti-photoaging properties. Partial skin of rats was irradiated with ultraviolet (UV) and injected with PRP, and the skin appearance, pathological state, and aging conditions were determined.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!