AI Article Synopsis
- Polycyclic ring-fused 2-pyridones were synthesized using a microwave-assisted technique that allows for efficient cyclocondensation.
- The process starts with 3,4-dihydroisoquinolines or 3,4-dihydroharman and can produce different mono- or disubstituted variants of 2-pyridones in one step.
- This method was also used to successfully perform a formal synthesis of the indole alkaloid sempervilam.
Article Abstract
Polycyclic ring-fused 2-pyridones (5a-e and 9a-e) have been prepared via a microwave-assisted acyl-ketene imine cyclocondensation. Starting from 3,4-dihydroisoquinolines (4a-b) or 3,4-dihydroharman (8), fused 2-pyridones could be prepared in a one-step procedure. By using either Meldrum's acid derivatives (1a-d) or 1,3-dioxine-4-ones (7a-b) as acyl-ketene sources, mono- or disubstitution of the fused 2-pyridone ring could be accomplished. As an application of the method, a formal synthesis of the indole alkaloid sempervilam was performed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ol052998e | DOI Listing |
Publication Analysis
Top Keywords
ring-fused 2-pyridones
8
acyl-ketene imine
8
imine cyclocondensation
8
synthesis multi
4
multi ring-fused
4
2-pyridones acyl-ketene
4
cyclocondensation polycyclic
4
polycyclic ring-fused
4
2-pyridones 5a-e
4
5a-e 9a-e
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!