Every practice has patients who complain of cold sensitivity and pain on biting while showing no obvious signs of irreversible pulpitis. After loading each cusp and fossa in a symptomatic quadrant and ruling out pulp and periodontal pathology, definitive treatment can be performed to alleviate the patient's symptoms in a consistent, conservative manner using esthetic computer-aided design/computer-aided manufacturing porcelain restorations. Single-appointment definitive restorations can be advantageous for the patient because of the elimination of many steps involved in laboratory fabrication of porcelain or metal restorations.
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J Sep Sci
January 2025
Zhejiang Provincial Key Laboratory of Evolutionary Ecology and Conservation, Taizhou University, Taizhou, China.
Evaluating the practical utility of endangered plant species is crucial for their conservation. Nevertheless, numerous endangered plants, including Sinocalycanthus chinensis, lack historical usage data, leading to a paucity of guidance in traditional pharmacological research. This gap impedes their development and potential utilization.
View Article and Find Full Text PDFHeliyon
December 2024
Institute of Geophysics and Geomatics, China University of Geosciences, Wuhan, 430074, China.
This study explores the optimization and performance of a hybrid energy system combining a geothermal heat pump (GHP) with a wind turbine in Izmir, Turkey. Utilizing a 4E (Energy, Exergy, Economic, and Exergoenvironmental) analysis approach, the system aims to enhance winter heating efficiency. Geothermal heat pumps leverage the Earth's consistent temperatures for heating and cooling, offering a sustainable alternative to traditional energy sources.
View Article and Find Full Text PDFBiotechnol Rep (Amst)
March 2025
Department of Sciences, Faculty of Science and Technology, Suan Sunandha Rajabhat University, Bangkok, 10300, Thailand.
Extracellular triacylglycerol hydrolases (ETH) play a critical role for microorganisms, acting as essential tools for lipid breakdown and survival in challenging environments. The pursuit of more effective ETH genes and enzymes through evolution holds significant potential for enhancing living conditions. This study employs a proteogenomic approach to identify high G+C ETH in a notable Gram-positive bacterium, .
View Article and Find Full Text PDFBiodivers Data J
December 2024
Department of Science, Roma Tre University, Viale G. Marconi, 446, Rome, Italy Department of Science, Roma Tre University, Viale G. Marconi, 446 Rome Italy.
Background: Urbanisation is a global phenomenon responsible for negative processes in natural ecosystems, such as degradation, loss of habitat and fragmentation. Large urban green areas could, however, represent shelter for animal species, promoting biodiversity conservation. Urban green spaces can also provide useful habitats for threatened species.
View Article and Find Full Text PDFOrg Biomol Chem
January 2025
School of Pharmaceutical Science and Technology, Hangzhou Institute of Advanced Study, Hangzhou 310024, China.
Glycosite-specific antibody-drug conjugates (gsADCs), which carry cytotoxic payloads at the conserved -glycosylation site, N297, of an IgG, have emerged as a promising ADC format with better therapeutic index. Conjugating the payloads aldehyde-based chemistry is more friendly to IgGs, and has been widely investigated. However, the efficiency of introducing an aldehyde tag at the N297 site is poor due to the complicated procedures required, such as the multiple-enzyme-catalyzed IgG glycoengineering process and the successive oxidation step, which always results in heterogeneous products and poor stability.
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