Objective: To investigate the expression of cyclooxygenase-2 in laryngeal squamous cell carcinoma and the correlation with tumor angiogenesis.
Method: The COX-2 and FVIII of 42 cases of laryngeal squamous cell carcinoma were detected by immunohistochemical SABC method,and the correlation between the expression rates, clinical significance and microvessel density(MVD) was analyzed.
Result: The positive rate of COX-2 in laryngeal squamous cell carcinoma tissues and adjacent normal tissues were 71.43% and 19.05% respectively. The expression of COX-2 were not associated with age, sex, tumor site and T stage. The tumors of grade III approximately IV showed a higher COX-2 expression than tumors of grade I approximately II did and the expression of COX-2 in the cervical lymph node metastasis group was higher than that in the non-metastasis group. The expression of COX-2 was closely associated with microvessel density(MVD) of laryngeal squamous cell carcinoma.
Conclusion: The expression of COX-2 may play a crucial role in the carcinogenesis and development of laryngeal squamous cell carcinoma and cervical lymph node metastasis in patients with laryngeal squamous cell carcinoma. COX-2 may be a important factor in tumor angiogenesis.
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