The methanolic extract of the aerial parts of Centipeda minima was found to show inhibitory activity on farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of 6-O-angeloylprenolin, as an inhibitor on FPTase. This compound inhibited FPTase activity in a dose-dependent manner, and the IC50 value of 6-O-angeloylprenolin was 18.8 microM.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
inhibitory activity
8
centipeda minima
8
farnesyl protein
8
protein transferase
8
methanolic extract
8
activity 6-o-angeloylprenolin
4
6-o-angeloylprenolin centipeda
4
minima farnesyl
4
transferase methanolic
4
extract aerial
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!