AI Article Synopsis
- The study evaluated the effectiveness of five antibiotics (levvofloxacin, amoxicillin, clarithromycin, metronidazole, and tetracycline) against 70 strains of Helicobacter pylori from patients with persistent digestive issues.
- A significant level of resistance was observed, with 65.7% of isolates resistant to clarithromycin, 57.1% to metronidazole, and 18.6% to levofloxacin.
- The findings suggest that physicians might consider a new treatment approach using triple therapy that combines omeprazole, levofloxacin, and amoxicillin for patients who have not responded to earlier treatments.
Article Abstract
We tested the in vitro activity of levofloxacin (LEV), amoxicillin (AMP), clarithromycin (CLA), metronidazole (MET), and tetracycline (TET) against 70 clinical isolates of Helicobacter pylori recovered from 70 dyspeptic patients. All patients had previously failed 2 treatment regimens: first-line triple therapy with omeprazole, AMP, and CLA, and second-line quadruple therapy with omeprazole, MET, TET, and bismuth. Resistance to CLA, MET, and LEV was found in 65.7%, 57.1%, and 18.6% of isolates, respectively. Resistance to both CLA and MET was found in 32.8%, and to CLA, MET, and LEV in 12.8%. Only 4 of the isolates were resistant to both CLA and LEV, and none was resistant to LEV alone or to MET and LEV. Physicians should consider triple therapy with omeprazole, LEV, and AMP in patients unsuccessfully treated with first- and second-line regimens.
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| http://dx.doi.org/10.1016/j.diagmicrobio.2005.12.003 | DOI Listing |
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