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Performance of the PhoP (Rv0757/Mb0780) protein as diagnostic antigen for bovine tuberculosis.
Res Vet Sci
December 2024
Instituto Nacional de Tecnología Agropecuaria, Instituto de Agrobiotecnología y Biología Molecular (IB-IABiMo), UEDD INTA-CONICET, Hurlingham, Buenos Aires, Argentina; CONICET, Argentina. Electronic address:
Bovine tuberculosis (bTB), a global zoonotic disease, causes negative effects on human and animal health. PhoP protein is a key regulator of pathogenic phenotypes in members of the Mycobacterium tuberculosis complex, which includes the causative agent of bTB. Despite extensive research on this protein focused in deciphering its regulatory role, little was explored about it as a diagnostic antigen.
View Article and Find Full Text PDFGetting to grips with the bovine tuberculosis biosecurity evidence base.
Vet Rec
January 2025
One Health Scientific Support Unit, Department of Agriculture, Food and the Marine, Dublin, Ireland.
A knowledge, attitude and practices assessment of control measures for bovine tuberculosis and brucellosis towards a more effective approach to national control programs in South Africa.
Trop Anim Health Prod
January 2025
Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, Onderstepoort, University of Pretoria, Pretoria, South Africa.
Bovine brucellosis and bovine tuberculosis are zoonotic diseases with economic and public health importance across the world, especially in developing countries where the diseases are endemic. The diseases are classified as neglected diseases in developing nations with poor resources despite good control measures in some developed countries. The purpose of this study is to assess the knowledge, attitudes and perceptions (KAP) of stakeholders towards control measures for bovine brucellosis (BR) and bovine tuberculosis (bTB) at a livestock-wildlife interface.
View Article and Find Full Text PDFReplication Kinetics, Pathogenicity and Virus-induced Cellular Responses of Cattle-origin Influenza A(H5N1) isolates from Texas, United States.
Emerg Microbes Infect
December 2024
Host-pathogen interactions (HPI) and Disease Intervention and Prevention (DIP) programs, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.
The host range of HPAIV H5N1 was recently expanded to include ruminants, particularly dairy cattle in the United States (US). Shortly after, human H5N1 infection was reported in a dairy worker in Texas following exposure to infected cattle. Herein, we rescued the cattle-origin influenza A/bovine/Texas/24-029328-02/2024(H5N1, rHPbTX) and A/Texas/37/2024(H5N1, rHPhTX) viruses, identified in dairy cattle and human, respectively, and their low pathogenic forms, rLPbTX and rLPhTX, with monobasic HA cleavage sites.
View Article and Find Full Text PDFEradication of bovine tuberculosis in Ireland: is it a case of now or never?
Ir Vet J
December 2024
Centre for Veterinary Epidemiology and Risk Analysis, School of Veterinary Medicine, UCD, University College Dublin, Belfield, Dublin, D04 W6F6, Ireland.
There has been a sharp disimprovement in the bovine tuberculosis (bTB) situation in Ireland in recent years. This commentary argues for critical programme change in three overarching themes relevant to the Irish bTB eradication programme, if eradication is to be successful: (1) Limiting infection in cattle. Residual (hidden) infection is an important constraint to eradication, due to the use of imperfect diagnostic tests.
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